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Effect of day-to-day variations in adrenal cortex hormone levels on abdominal symptoms

机译：肾上腺皮质激素水平的每日变化对腹部症状的影响

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Introduction The hypothalamic-pituitary-adrenal axis is known to be related to abdominal symptoms, and the relationship between abdominal pain and cortisol secretory patterns has been previously investigated using a cross-sectional approach. Here, we investigated the effect of day-to-day variations in salivary cortisol and dehydroepiandrosterone-sulfate levels on abdominal symptoms in healthy individuals. Methods Eleven college students (4 males and 7 females) participated in this study. The participants were asked to collect their saliva immediately after awakening and before bedtime for eight consecutive days. They also completed a questionnaire about abdominal symptoms before bedtime. The linear mixed model was applied to analyze the effects of the day-by-day variability or the 8-day average adrenal hormone level (at awakening, before bedtime, slope from awakening to bedtime) on abdominal symptoms. Results The day-to-day variability of cortisol levels before bedtime was negatively related with loose stool, while the day-to-day variability of the cortisol slope was positively correlated with loose stool. A low 8-day average dehydroepiandrosterone-sulfate level at awakening was positively related with frequent bowel movements, loose stool, and long bouts of severe abdominal pain. Likewise, a low 8-day average dehydroepiandrosterone-sulfate slope was positively related with long bouts of abdominal pain. Conclusions Low cortisol levels before bedtime and a steeper diurnal cortisol slope during the day may be related to bouts of diarrhea during the day.
机译：简介已知下丘脑-垂体-肾上腺轴与腹部症状有关，并且先前已使用横断面方法研究了腹痛与皮质醇分泌模式之间的关系。在这里，我们调查了健康个体的唾液皮质醇和脱氢表雄酮硫酸盐水平的每日变化对腹部症状的影响。方法11名大学生（男4女，女7）参加了本研究。要求参与者在醒后和就寝前连续八天收集唾液。他们还完成了就寝前腹部症状的问卷调查。应用线性混合模型分析每日变化或8天平均肾上腺激素水平（觉醒时，就寝前，觉醒至就寝时间的斜率）对腹部症状的影响。结果就寝前皮质醇水平的日常变化与粪便稀少呈负相关，而皮质醇斜率的日常变化与粪便稀少呈正相关。唤醒时平均8天的低脱氢表雄酮硫酸盐水平与频繁的排便，大便稀疏和长时间的剧烈腹痛呈正相关。同样，平均8天的低脱氢表雄酮硫酸盐斜率与长时间的腹痛呈正相关。结论就寝前皮质醇水平较低，白天皮质醇斜率较陡，可能与白天腹泻有关。

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