• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BioPsychoSocial Medicine >Is the association between optimistic cardiovascular risk perceptions and lower rates of cardiovascular disease mortality explained by biomarkers of systemic inflammation or endothelial function? A case-cohort study
【24h】

Is the association between optimistic cardiovascular risk perceptions and lower rates of cardiovascular disease mortality explained by biomarkers of systemic inflammation or endothelial function? A case-cohort study

机译：是否通过全身性炎症或内皮功能的生物标志物解释了乐观的心血管风险认知与较低的心血管疾病死亡率之间的关联？个案研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background More optimistic perceptions of cardiovascular disease risk are associated with substantively lower rates of cardiovascular death among men. It remains unknown whether this association represents causality (i.e. perception leads to actions/conditions that influence cardiovascular disease occurrence) or residual confounding by unmeasured factors that associate with risk perceptions and with physiological processes that promote cardiovascular disease (i.e. inflammation or endothelial dysfunction). Purpose To evaluate whether previously unmeasured biological markers of inflammation or endothelial dysregulation confound the observed association between cardiovascular disease risk perceptions and cardiovascular disease outcomes; Methods We conducted a nested case-cohort study among community-dwelling men from Southeastern New England (USA) who were interviewed between 1989 and 1990 as part of the Pawtucket Heart Health Program. We measured C-reactive protein (CRP) and Vascular Endothelial Growth Factor (VEGF) levels from stored sera for a random sample of the parent cohort (control sample, n = 127) and all cases of cardiovascular death observed through 2005 (case sample, n = 44). We evaluated potential confounding using stratified analyses and logistic regression modeling. Results Optimistic ratings of risk associated with lower odds of dying from cardiovascular causes among men (OR = 0.39, 95% CI = 0.17, 0.91). Neither CRP nor VEGF confounded these findings. Conclusions The strong cardio-protective association between optimistic ratings of cardiovascular disease risk and lower rates of cardiovascular mortality among men is not confounded by baseline biomarkers of systemic inflammation or endothelial dysfunction.
机译：背景技术对心血管疾病风险的更乐观的看法与男性心血管死亡率的显着降低有关。这种联系是否代表因果关系（即知觉导致影响心血管疾病发生的行为/条件）或与风险知觉和促进心血管疾病的生理过程（即炎症或内皮功能障碍）相关的无法衡量的因素造成的残余混杂，仍然未知。目的评估先前无法测量的炎症或内皮失调的生物标志物是否混淆了心血管疾病风险认知与心血管疾病预后之间的关联性;方法我们对来自新英格兰东南部（美国）的社区居民进行了嵌套的病例队列研究，他们在1989年至1990年期间接受了Pawtucket心脏健康计划的采访。我们从父母队列的随机样本（对照样本，n = 127）以及直至2005年观察到的所有心血管死亡病例（病例样本，从样本中收集的血清）中，测量了储存血清中的C反应蛋白（CRP）和血管内皮生长因子（VEGF）水平n = 44）。我们使用分层分析和逻辑回归模型评估了潜在的混淆。结果男性因心血管原因死亡的机率较低的风险的乐观评级（OR = 0.39，95％CI = 0.17，0.91）。 CRP和VEGF均未混淆这些发现。结论男性心血管疾病风险的乐观评级与较低的心血管疾病死亡率之间的强心脏保护关联并未与全身性炎症或内皮功能障碍的基线生物标志物混淆。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号