Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder?

Yutaka Matsuoka

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Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder?

机译：通过omega-3脂肪酸通过神经发生清除海马恐惧记忆：创伤后应激障碍的新预防策略？

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Not only has accidental injury been shown to account for a significant health burden on all populations, regardless of age, sex and geographic region, but patients with accidental injury frequently present with the psychiatric condition of posttraumatic stress disorder (PTSD). Prevention of accident-related PTSD thus represents a potentially important goal. Physicians in the field of psychosomatic medicine and critical care medicine have the opportunity to see injured patients in the immediate aftermath of an accident. This article first briefly reviews the prevalence and associated factors of accident-related PTSD, then focuses on a conceptual model of fear memory and proposes a new, rationally hypothesized translational preventive intervention for PTSD through promoting hippocampal neurogenesis by omega-3 fatty acid supplementation. The results of an open-label pilot trial of injured patients admitted to the intensive care unit suggest that omega-3 fatty acid supplementation immediately after accidental injury can reduce subsequent PTSD symptoms.

机译：不仅表明意外伤害对所有人群造成了巨大的健康负担，无论其年龄，性别和地理区域如何，而且意外伤害患者经常表现出创伤后应激障碍（PTSD）的精神病状态。因此，预防与事故有关的PTSD是一个潜在的重要目标。心身医学和重症监护医学领域的医师有机会在事故发生后立即去看受伤的患者。本文首先简要回顾了与事故相关的PTSD的患病率及其相关因素，然后重点介绍了恐惧记忆的概念模型，并提出了一种新的合理假设的，通过补充omega-3脂肪酸促进海马神经发生的PTSD转化预防干预措施。接受重症监护室治疗的受伤患者的开放标签试验研究的结果表明，意外伤害后立即补充omega-3脂肪酸可以减轻随后的PTSD症状。

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《BioPsychoSocial Medicine》 |2011年第1期|共页
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Yutaka Matsuoka;
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中图分类心理学;
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1. The Effect of Omega-3 Fatty Acids on Psychophysiological Assessment for the Secondary Prevention of Posttraumatic Stress Disorder: An Open-Label Pilot Study [J] . Kenta Matsumura, Hiroko Noguchi, Daisuke Nishi, Global Journal of Health Science . 2011,第1期

机译：Omega-3脂肪酸在心理生理评估中对创伤后应激障碍的二级预防的作用：一项开放标签试验研究
2. Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment [J] . Laiali Alquraan, Karem H. Alzoubi, Hana Hammad, Biomolecules . 2019,第3期

机译：Omega-3脂肪酸可预防创伤后应激障碍引起的记忆障碍
3. Further Exploring the Associations Between Sympathetic Activation, Fear of Sleep, and Insomnia Symptoms in Posttraumatic Stress Disorder Response to Gupta and Sheridan. Fear of sleep may be a core symptom of sympathetic activation and the drive for vigilance in posttraumatic stress disorder. J Clin Sleep Med. 2018;14(12):2093 [J] . Kanady Jennifer C., Maguen Shira, Neylan Thomas C. Journal of clinical sleep medicine: JCSM : official publication of the American Academy of Sleep Medicine . 2018,第12期

机译：进一步探讨了同情激活，对睡眠恐惧和失眠症状的协会对Gupta和Sheridan的响应后特性应激障碍的症状。恐惧睡眠可能是交感神经激活的核心症状，并且在创伤性应激障碍中警惕的驱动。 J Clin Sleep Med。 2018; 14（12）：2093
4. Omega-3 Fatty Acids Improves Oxidative Stress in Women with Polycystic Ovary Syndrome [C] . Maryam Rafraf, Elahe mohamadi 14th ICC cereal and bread congress and forum on fats amp; oils : Science and technology innovation for healthy cereals amp; oils : book of abstracts . 2012

机译：Omega-3脂肪酸改善多囊卵巢综合征女性的氧化应激
5. Cognitive Sequelae of Trauma: Memory and Attention Deficits in Individuals Diagnosed with Posttraumatic Stress Disorder, Mild Traumatic Brain Injury, and Comorbid Posttraumatic Stress Disorder/Mild Traumatic Brain Injury. [D] . Freece, Krista L. 2011

机译：创伤的认知后遗症：被诊断为创伤后应激障碍，轻度创伤性脑损伤和合并症的创伤后应激障碍/轻度创伤性脑损伤的个体的记忆力和注意力不足。
6. Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder? [O] . Yutaka Matsuoka 2011

机译：通过omega-3脂肪酸通过神经发生清除海马恐惧记忆：创伤后应激障碍的新预防策略？
7. Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder? [O] . Matsuoka Yutaka 2011

机译：通过omega-3脂肪酸通过神经发生清除海马恐惧记忆：创伤后应激障碍的新预防策略？
8. Omega-3 Fatty Acids for Major Depressive Disorder: A Systematic Review. [R] . Newberry, S., Hempel, S., Booth, M., 2015

机译：重度抑郁症的Omega-3脂肪酸：系统评价。

Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder?

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