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Pilot study of fluvoxamine treatment for climacteric symptoms in Japanese women

机译：氟伏沙明治疗日本女性更年期症状的初步研究

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Background Selective serotonin-reuptake inhibitors (SSRIs) are commonly prescribed for the treatment of depression and can be used as nonhormonal alternatives to manage hot flashes for women with a history of breast cancer and unable to take hormone replacement therapy. There are, however, few reports on the efficacy of SSRIs for the treatment of natural postmenopausal climacteric symptoms. In this pilot study, we evaluate the SSRI, fluvoxamine, for controlling climacteric symptoms and vasomotor symptoms, in particular. Methods Twenty-two patients were enrolled from our hospital. All were orally administered fluvoxamine (50 mg daily). Climacteric and depressive symptoms were assessed using simple menopausal index (SMI) and self-rating questionnaire for depression (SRQ-D), respectively, at baseline, and at 2 and 6 weeks post-treatment. Results Six weeks following drug administration, neither the SRQ-D nor SMI scores significantly decreased compared to baseline. The mean levels of vasomotor symptoms and mental symptoms decreased significantly following fluvoxamine administration, while skeletal muscle symptom scores did not. Conclusion We were able to demonstrate that fluvoxamine was effective in treating not only depressive moods in climacteric symptoms but also the associated vasomotor symptoms. There are several limitations to this preliminary study. Future controlled studies are needed to further evaluate the efficacy of fluvoxamine for climacteric disturbances.
机译：背景技术选择性5-羟色胺再摄取抑制剂（SSRIs）通常用于治疗抑郁症，并且可以用作非激素替代品，用于治疗有乳腺癌史且无法采取激素替代疗法的女性潮热。然而，关于SSRIs治疗绝经后自然更年期症状的功效的报道很少。在这项先导研究中，我们评估了SSRI氟伏沙明特别是用于控制更年期症状和血管舒缩症状。方法选择我院收治的22例患者。全部口服氟伏沙明（每日50 mg）。使用简单的更年期指数（SMI）和抑郁自评问卷（SRQ-D）分别在基线，治疗后2周和6周评估更年期和抑郁症状。结果给药六周后，SRQ-D和SMI评分均未明显低于基线。氟伏沙明给药后，血管舒缩症状和精神症状的平均水平显着降低，而骨骼肌症状评分未升高。结论我们能够证明氟伏沙明不仅可以治疗更年期症状的抑郁情绪，而且可以治疗相关的血管舒缩症状。这项初步研究存在一些局限性。需要进一步的对照研究，以进一步评估氟伏沙明对更年期疾病的疗效。

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