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首页> 外文期刊>BioPsychoSocial Medicine >Does psychological status influence clinical outcomes in patients with inflammatory bowel disease (IBD) and other chronic gastroenterological diseases: An observational cohort prospective study
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Does psychological status influence clinical outcomes in patients with inflammatory bowel disease (IBD) and other chronic gastroenterological diseases: An observational cohort prospective study

机译：心理状态是否会影响炎症性肠病（IBD）和其他慢性胃肠病患者的临床结局：一项观察性队列前瞻性研究

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Background Whether there is a temporal relationship between psychological problems and clinical outcomes in patients with diseases of the digestive tract has not been widely researched. Thus, our aims were 1) To observe and compare prospectively clinical outcomes in relation to psychological co-morbidity in patients with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and chronic hepatitis C (HCV) and, 2) To test the hypothesis that patients with psychological co-morbidities are less likely to have a satisfactory response to standard treatment at 12 months. Methods Overall, 139 patients were enrolled in this observational cohort prospective study. Over the ensuing year, physical and psychological measures were made at baseline and after 12 months (HADS, SCL90, SF-12 and disease activity measures). A logistic regression was conducted to observe any relationship between baseline characteristics and patients' clinical outcomes after 12 months. Results Overall, there was no relationship between psychological status and quality of life at baseline and relapse at 12 months (p > 0.05). However, patients with inactive disease at baseline were at lower risk of relapse after 12 months (OR = 0.046, CI: 0.012–0.178). No significant relationship was found between psychological problems such as depression/anxiety and a total number of relapses in the IBD group. However, interestingly, patients with an active disease at baseline tended to have a greater number of relapses (OR = 3.07, CI: 1.650–5.738) and CD participants were found at lower risk of relapse than UC participants (OR = 0.382, CI: 0.198–0.736). Conclusion In contrast to previous investigations, this study suggests that there is no temporal relationship between psychological problems at baseline and clinical outcomes over time. Longer and larger prospective studies are needed to better understand this result.
机译：背景技术消化道疾病患者的心理问题与临床结局之间是否存在时间关系尚未得到广泛研究。因此，我们的目标是：1）观察和比较炎症性肠病（IBD），肠易激综合征（IBS）和慢性丙型肝炎（HCV）患者与心理合并症相关的前瞻性临床结果，以及2）测试假设有心理并发症的患者在12个月内对标准治疗的满意度较低。方法总共139名患者参加了这项观察性队列前瞻性研究。在接下来的一年中，在基线和12个月后进行了生理和心理测量（HADS，SCL90，SF-12和疾病活动测量）。进行逻辑回归分析以观察12个月后基线特征与患者临床结果之间的任何关系。结果总体而言，基线时的心理状态与生活质量以及12个月的复发之间均无相关性（p> 0.05）。但是，基线时处于非活动状态的患者在12个月后复发的风险较低（OR = 0.046，CI：0.012-0.178）。在IBD组，诸如抑郁/焦虑之类的心理问题与复发总数之间没有发现显着关系。然而，有趣的是，基线时患有活动性疾病的患者往往有更多的复发（OR = 3.07，CI：1.650–5.738），发现CD参与者的复发风险低于UC参与者（OR = 0.382，CI： 0.198–0.736）。结论与以往的研究相反，该研究表明，基线时的心理问题与一段时间内的临床结局之间没有时间上的关系。需要更长和更大的前瞻性研究来更好地理解这一结果。

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