...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Balkan journal of medical genetics: BJMG >Inherited thrombophilias could influence the reproductive outcome in women with systemic lupus erythematosus
【24h】

Inherited thrombophilias could influence the reproductive outcome in women with systemic lupus erythematosus

机译：遗传性血友病可能影响系统性红斑狼疮妇女的生殖结局

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with different reproductive complications in the affected women. Inherited thrombophilias are genetic factors increasing the risk for thromboembolism and recurrent pregnancy loss, but their influence on other reproductive disturbances in SLE patients has not been completely clarified. Two hundred and twenty-three Caucasian women (112 with SLE and 111 controls) were included in the study. Complete reproductive history of all SLE patients was carefully obtained. Genotyping for the FVLeiden, FIIG20210A, and MTHFRC677T polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. No significant differences in the prevalence of the FVLeiden, FIIG20210A, and MTHFRC677T polymorphisms between patients and controls were established. Patients with FVLeiden had fewer pregnancies (0.57 ?± 0.98 vs. 2.18 ?± 1.58; p = 0.007) than the others, while no significant differences in the reproductive history of FIIG20210A carriers and non-carriers were observed (p >0.05). In the SLE group, 41.67% of women with the MTHFRC677T TT genotype had at least one miscarriage in comparison to only 14.00% of the other female patients (p = 0.030). While the prevalence of the investigated thrombophilias was similar in patients with SLE and healthy women, a substantial influence of the inherited prothrombotic factors on the reproductive history of patients was revealed. The investigations of the FVLeiden and MTHFRC677T polymorphisms in SLE patients could help to identify women at highest risk for reproductive failure and thus, further studies in other ethnic groups would be of strong clinical importance.
机译：系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，与受影响妇女的不同生殖并发症相关。遗传性血友病是增加血栓栓塞和复发性流产风险的遗传因素，但尚未完全阐明其对SLE患者其他生殖功能障碍的影响。这项研究包括了223名白人妇女（112名SLE和111名对照）。仔细获取所有SLE患者的完整生殖史。 FVLeiden，FIIG20210A和MTHFRC677T多态性的基因分型通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析进行。在患者和对照之间未发现FVLeiden，FIIG20210A和MTHFRC677T多态性的发生率有显着差异。 FVLeiden患者的妊娠率较其他患者少（0.57±0.98 vs. 2.18±1.58; p = 0.007），而未观察到FIIG20210A携带者和非携带者的生育史差异显着（p> 0.05）。在SLE组中，具有MTHFRC677T TT基因型的女性中有41.67％至少有一次流产，而其他女性患者中只有14.00％（p = 0.030）。尽管在SLE患者和健康女性中，所研究的血友病患病率相似，但揭示了遗传性血栓形成因子对患者生殖史的重大影响。对SLE患者中FVLeiden和MTHFRC677T基因多态性的研究可能有助于鉴定出生殖功能衰竭风险最高的妇女，因此，在其他种族中进行进一步研究将具有重要的临床意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号