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首页> 外文期刊>Balkan journal of medical genetics: BJMG >INHERITED THROMBOPHILIAS COULD INFLUENCE THE REPRODUCTIVE OUTCOME IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS
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INHERITED THROMBOPHILIAS COULD INFLUENCE THE REPRODUCTIVE OUTCOME IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS

机译：遗传血栓药可以影响狼疮红斑狼疮的妇女的生殖结果

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with different reproductive complications in the affected women. Inherited thrombophilias are genetic factors increasing the risk for thromboembolism and recurrent pregnancy loss, but their influence on other reproductive disturbances in SLE patients has not been completely clarified. Two hundred and twenty-three Caucasian women (112 with SLE and 111 controls) were included in the study. Complete reproductive history of all SLE patients was carefully obtained. Genotyping for the FVLeiden, FIIG20210A, and MTHFRC677T polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. No significant differences in the prevalence of the FVLeiden, FIIG20210A, and MTHFRC677T polymorphisms between patients and controls were established. Patients with FVLeiden had fewer pregnancies (0.57 +/- 0.98 vs. 2.18 +/- 1.58; p = 0.007) than the others, while no significant differences in the reproductive history of FIIG20210A carriers and non-carriers were observed (p >0.05). In the SLE group, 41.67% of women with the MTHFRC677T TT genotype had at least one miscarriage in comparison to only 14.00% of the other female patients (p = 0.030). While the prevalence of the investigated thrombophilias was similar in patients with SLE and healthy women, a substantial influence of the inherited prothrombotic factors on the reproductive history of patients was revealed. The investigations of the FVLeiden and MTHFRC677T polymorphisms in SLE patients could help to identify women at highest risk for reproductive failure and thus, further studies in other ethnic groups would be of strong clinical importance.
机译：Systemic Lupus红斑（SLE）是一种慢性自身免疫疾病，与受影响女性不同的生殖并发症相关。遗传性血栓血管基是遗传因素，增加了血栓栓塞和复发性妊娠损失的风险，但它们对SLE患者中其他生殖紊乱的影响尚未完全阐明。研究中包含二百二十三名白种人女性（112名带SLE和111个控制）。仔细获得所有SLE患者的完全生殖历史。通过聚合酶链反应限制片段长度多态性（PCR-RFLP）分析，进行FVLEIDEN，FIIG20210A和MTHFRC677T多态性的基因分型。建立了FVLEIDEN，FIIG20210A和患者与对照之间的多态性的普遍性的显着差异。 Fvleiden患者的怀孕较少（0.57 +/- 0.98，比例为2.18 +/- 1.58; p = 0.007），而观察到Fiig20210A载体和非携带者的生殖史没有显着差异（P> 0.05） 。在SLE集团中，41.67％的患有MTHFRC677T TT基因型的女性至少有一个流产，与其他女性患者的仅占14.00％（P = 0.030）。虽然SLE和健康女性患者的研究血栓性患者的患病率相似，但揭示了遗传性癌细胞因素对患者生殖病史的重大影响。 SLE患者的FVLEIDEN和MTHFRC677T多态性的研究可以帮助鉴定生殖失败的最高风险的女性，因此，其他族裔的进一步研究将具有强烈的临床重要性。

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