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首页> 外文期刊>BMC Complementary and Alternative Medicine >A system biology approach to understanding the molecular mechanisms of Gubentongluo decoction acting on IgA Nephropathy
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A system biology approach to understanding the molecular mechanisms of Gubentongluo decoction acting on IgA Nephropathy

机译：系统生物学方法了解古本通络汤对IgA肾病作用的分子机制

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Background Traditional Chinese medicine (TCM) has been widely used in treating various diseases in eastern Asia for several thousand years, and is becoming increasingly popular in western countries. Gubentongluo (GBTL) decoction, as a classic TCM formula, is commonly applied to treat IgA Nephropathy (IgAN) in China. To date, however, the pharmacological/molecular mechanisms of GBTL have not been fully elucidated. Method In the present study, we used a system biological approach to explore these mechanisms acting on IgAN. Results First, we found 3876 potential target proteins for GBTL (based on TCMID) and 25 known IgAN associated biomarkers (based on the OMIM or IPA database).16 of the latter biomarkers were direct targets of 6 of the 9 herbs in GBTL, suggesting that these components play a vital role in treating IgAN. Second, we showed that these 6 herbs mainly regulate the immune system and renin-angiotensin system, imbalance in which is the main factor leading to IgAN. Importantly, HUANG QI links with 14 biomarkers, indicating that it is the most important herb in GBTL for treating IgAN. Also, relationships of other herbs with IgAN were explored. Third, we demonstrated that the remaining 9 IgAN associated proteins are responses to biological processes, such as antigen processing, protein ubiquitination and cell cycle regulation, which are crucial for IgAN development. Finally, we found that GBTL could induce a significant increase in the levels of two target gene: TNF and NOS2. Conclusions Further studies are called to develop/modify the formula of GBTL, in order to enhance its effect on IgAN.
机译：背景技术中医药（TCM）在东亚已经广泛用于治疗各种疾病，已有数千年的历史，并且在西方国家越来越受欢迎。古本通络汤（GBTL）是一种经典的中药配方，在中国通常用于治疗IgA肾病（IgAN）。然而，迄今为止，尚未完全阐明GBTL的药理/分子机制。方法在本研究中，我们使用系统生物学方法探索了这些作用于IgAN的机制。结果首先，我们发现了3876个潜在的GBTL靶蛋白（基于TCMID）和25个已知的IgAN相关生物标记（基于OMIM或IPA数据库）。后者中的16个是GBTL 9种草药中6种的直接靶标，表明这些成分在治疗IgAN中起着至关重要的作用。其次，我们发现这6种草药主要调节免疫系统和肾素-血管紧张素系统，其中不平衡是导致IgAN的主要因素。重要的是，黄芪与14种生物标志物相关联，表明它是GBTL中治疗IgAN最重要的草药。此外，还探讨了其他草药与IgAN的关系。第三，我们证明了剩下的9个IgAN相关蛋白是对生物学过程的响应，例如抗原加工，蛋白泛素化和细胞周期调控，这对IgAN的发展至关重要。最后，我们发现GBTL可以诱导两个靶基因TNF和NOS2的水平显着增加。结论需要进一步研究以开发/修改GBTL的配方，以增强其对IgAN的作用。

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