首页> 外文期刊>BMC Dermatology >Mapping randomized controlled trials of treatments for eczema - The GREAT database (The Global Resource of Eczema Trials: a collection of key data on randomized controlled trials of treatments for eczema from 2000 to 2010)
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Mapping randomized controlled trials of treatments for eczema - The GREAT database (The Global Resource of Eczema Trials: a collection of key data on randomized controlled trials of treatments for eczema from 2000 to 2010)

机译:绘制湿疹治疗随机对照试验图-GREAT数据库(全球湿疹试验资源:2000年至2010年治疗湿疹随机对照试验关键数据的集合)

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Background Massive duplication of effort occurs when researchers all over the world undertake extensive searches for randomized controlled trials when preparing systematic reviews, when developing evidence-based guidelines and when applying for research funding for eczema treatments. Such duplication wastes valuable resources. Searching for randomized controlled trials of eczema is a laborious task involving scrutiny of thousands of individual references from diverse electronic databases in order to obtain a few papers of interest. Clinicians and patients who wish to find out more about a particular treatment are at risk of missing the relevant evidence if they are not trained in electronic bibliographic searching. Systematic reviews cannot be relied upon to comprehensively inform current optimal eczema treatments due to incomplete coverage and because many may be out of date. An international, publically available and comprehensive resource which brings together all randomized controlled trials on eczema treatment using a highly sensitive search has the potential to release more filtered knowledge about patient care to those who need it most and to significantly shorten the duration and costs of many clinical eczema research and guideline projects. Description The G lobal R esource of E czem A ? T rials brings together information on all randomized controlled trials of eczema treatments published from the beginning of 2000 up to the end of 2010 and will be updated every month. We searched the Cochrane Central Register of Controlled Trials in The Cochrane Library and the Cochrane Skin Group Specialised Register, MEDLINE, EMBASE, LILACS, AMED and CINHAL databases. We included 268 RCTs (24th March 2011) covering over 70 different treatment interventions. The structure of the Global Resource of Eczema Trials allows the user as much, or as little, specificity when retrieving information on trials as they wish, in an easy to use format. For each trial, the database gives the citation for the published report and also provides enough information to enable a user to decide whether the trial is worth further scrutiny. Conclusions The Global Resource of Eczema Trials has been created to facilitate knowledge mobilization into healthcare and to reduce wastage of research time through unnecessary duplication. The collective time saved by research groups around the world can now be used to make strides in optimising the treatment of eczema, in order to further benefit people with eczema. The database can be accessed free of charge at http://www.greatdatabase.org.uk webcite
机译:背景技术当全世界的研究人员在准备系统评价,制定循证指南以及申请湿疹治疗的研究经费时,对随机对照试验进行广泛搜索时,就会发生大规模的重复劳动。这样的重复浪费了宝贵的资源。寻找湿疹的随机对照试验是一项艰巨的任务,涉及对来自不同电子数据库的数千个个人参考文献进行仔细检查,以获取感兴趣的论文。如果临床医生和患者未接受电子书目搜索方面的培训,则有可能错过相关证据的风险。由于覆盖范围不完整,而且由于许多可能已过时,因此不能依靠系统的评估来全面了解当前的最佳湿疹治疗方法。一个国际公开可用的综合资源,它通过高度敏感的搜索将湿疹治疗的所有随机对照试验汇总在一起,有可能向最需要的人释放更多有关患者护理的过滤知识,并显着缩短许多护理的时间和成本临床湿疹研究和指南项目。描述E czem A的全球资源?从2000年初至2010年底发布的所有湿疹治疗随机对照试验的信息,并将每月更新。我们在Cochrane库中搜索了Cochrane对照试验的中央注册系统,并在Cochrane皮肤组专用注册系统,MEDLINE,EMBASE,LILACS,AMED和CINHAL数据库中进行了搜索。我们纳入了268项RCT(2011年3月24日),涵盖了70多种不同的治疗干预措施。湿疹试验全球资源的结构允许用户以易于使用的格式检索试验所需的信息时,或多或少的特异性。对于每个试验,数据库都给出了已发布报告的引用,还提供了足够的信息以使用户能够确定该试验是否值得进一步审查。结论创建了全球湿疹试验资源,以促进知识动员到医疗保健中,并通过不必要的重复来减少研究时间的浪费。现在,全球研究小组节省的集体时间可用于在优化湿疹治疗方面取得长足进步,从而进一步使湿疹患者受益。可以从http://www.greatdatabase.org.uk免费访问该数据库。

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