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首页> 外文期刊>BioTechnology: An Indian Journal >Systemic side effect in lipodissolve using phosphatidylcholine and deoxycholate containing formula: A systematic review
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Systemic side effect in lipodissolve using phosphatidylcholine and deoxycholate containing formula: A systematic review

机译：使用磷脂酰胆碱和脱氧胆酸盐的配方在脂溶性药物中的全身性副作用：系统评价

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Background: The use of phosphatidylcholine (PC) and deoxychholate (DC) as injection to remove unwanted fat pads is banned in some countries, and has not been approved by United States Food and DrugAdministration. This condition triggered attempts of lipodissolve practitioners to fight for the approval of PC/DCuse for lipodissolve purposes. They claimed that PC/DC injections do not cause serious systemic side effect. Aim: To systematically reviewthe original studies on the use of PC/DC for lipolysis of unwanted fat deposits to get a better understanding on the systemic side effects.Methods:All text search using keywords: ???phosphatidylcholine ??? or ???deoxycholate??? in combination with ???lipolysis??? and ???clinical trial??? or ???case report??? or ???pilot study???. Data extracted were: number of study participants, injection site, lipolytic agent, depth of injection, total volume, and systemic side effects. Total amount of PC/DC and systemic side effects were compared. Further, search for the explanations for possible causes of the various systemic side effects were done. Results: 9 of 25 articles reported systemic side effects including acute liver dysfunction and acute renal failure. Conclusion: High total DC concentration is supposed to be the major cause of severe inflammation that may lead to serious systemic side effects.
机译：背景：在某些国家/地区，禁止使用磷脂酰胆碱（PC）和脱氧胆酸盐（DC）注射以去除多余的脂肪垫，并且尚未得到美国食品药品监督管理局的批准。这种情况触发了脂溶性从业者尝试为脂溶性目的争取PC / DCuse的批准。他们声称PC / DC注射不会引起严重的全身性副作用。目的：系统地回顾有关使用PC / DC进行脂肪沉积的脂肪分解的原始研究，以更好地了解系统性副作用。方法：全文搜索使用关键词：磷脂酰胆碱或“脱氧胆酸盐”与脂解结合和“临床试验”或“案例报告”或?????????。提取的数据为：研究参与者的数量，注射部位，脂肪分解剂，注射深度，总体积和全身性副作用。比较了PC / DC的总量和全身性副作用。此外，进行了寻找各种系统性副作用的可能原因的解释。结果：25篇文章中有9篇报道了全身性副作用，包括急性肝功能不全和急性肾衰竭。结论：高的总DC浓度被认为是严重炎症的主要原因，可能导致严重的全身性副作用。

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