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首页> 外文期刊>BMC Cancer >Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma
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Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma

机译：饮食中叶酸，MTHFR C677T的DNA甲基化和遗传多态性与食管鳞状细胞癌的预后相关

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Background Folic acid may affect the development of human cancers. However, few studies have evaluated the consumption of diet folate in the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Methods One hundred and twenty five ESCC patients underwent esophagectomy between January 2005 and March 2006 in the Yangzhong People's Hospital were recruited and followed up. The effects of diet folate, aberrant DNA methylation of selected genes and methylenetetrahydrofolate reductase ( MTHFR ) C677T genetic polymorphisms on the prognosis of ESCC were evaluated by using Cox proportional hazard regression models. Results Our analysis showed an inverse association between diet folate intake and the risk of death after esophagectomy. The median survival time was 3.06 years for low or moderate folate consumption and over 4.59 years for high folate consumption. After adjusting for potential confounders, the hazard ratios (95% confidence interval) [HRs (95% CI)] were 0.72 (0.36-1.46) for moderate and 0.39 (0.20-0.78) for high folate intake, respectively ( P for trend = 0.007). This preventive effect was more evident in patients carrying MTHFR 677CC genotype. No significant relation was observed between aberrant DNA methylation of P16 , MGMT and hMLH1 gene, as well as MTHFR C677T genetic polymorphisms and the prognosis of ESCC. Conclusions Our research indicated that diet folate intake may have benefits on the prognosis of ESCC after esophagectomy. From a practical viewpoint, the findings of our study help to establish practical intervention and surveillance strategies for managements of ESCC patients and can finally decrease the disease burden.
机译：背景叶酸可能会影响人类癌症的发展。然而，很少有研究评估饮食中叶酸的摄入对食管鳞状细胞癌（ESCC）患者的预后。方法对2005年1月至2006年3月在扬中市人民医院行食管切除术的ESCC患者125例进行随访。采用Cox比例风险回归模型评估了日粮叶酸，所选基因的异常DNA甲基化和亚甲基四氢叶酸还原酶（MTHFR）C677T基因多态性对ESCC预后的影响。结果我们的分析表明，饮食中叶酸的摄入与食管切除术后死亡的风险呈负相关。中低叶酸摄入量的中位生存时间为3.06年，高叶酸摄入量的中位生存时间为4.59年以上。调整潜在混杂因素后，中叶摄入量的危险比（95％置信区间）[HRs（95％CI）]分别为0.72（0.36-1.46）和0.39（0.20-0.78）（P =趋势= 0.007）。这种预防作用在携带MTHFR 677CC基因型的患者中更为明显。 P16，MGMT和hMLH1基因的异常DNA甲基化以及MTHFR C677T基因多态性与ESCC的预后之间没有显着相关性。结论我们的研究表明，饮食中叶酸的摄入可能对食管切除术后ESCC的预后有所帮助。从实践的角度来看，我们的研究结果有助于为ESCC患者的治疗建立实用的干预和监测策略，并最终减轻疾病负担。

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