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首页> 外文期刊>BMC Medical Genomics >Experiences and attitudes of residents regarding a community-based genome cohort study in Japan: a population-based, cross-sectional study
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Experiences and attitudes of residents regarding a community-based genome cohort study in Japan: a population-based, cross-sectional study

机译：日本居民对基于社区的基因组队列研究的经验和态度：基于人群的横断面研究

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Background Because of the rapid development in genomics, more research findings have emerged. However, the association between society and research results remains controversial. This article examines the experiences and attitudes of residents regarding a community-based genomic cohort study. Methods This study was conducted as a part of the health survey of the City Health Promotion section. At the conclusion of the first stage of the project, a self-administered questionnaire was mailed to a random sample of 2,500 residents in 2012. Results The response rate was 59?% ( n =?1477/2500). The findings show that 70 % of males and 50 % of females knew nothing about the project. Females and elderly people were more likely to have knowledge of the study, indicating that self-rated understanding of the terminology is statistically associated with the level of awareness regarding the project. In addition, those who were aware of the project were also aware of the benefits of research utilizing genetic information, whereas unaware respondents, particularly males, believed that unexpected negative effects may occur. Those with higher self-rated understanding of the terminology and higher awareness of benefit of the research utilizing genetic information had more positive attitudes toward undergoing drug susceptibility genetic testing, indicating that the awareness of project in females and concerns toward genetic research are not statistically associated with the willingness to undergo. Conclusions This study suggests that a community-based genome cohort project helps raise awareness of benefit of genetic research and that knowledge, however, does not directly affect the willingness to participate in related activities, such as drug susceptibility genetic testing. Therefore, additional research that focuses on the circular relationship between risk and action must be conducted in the future.
机译：背景技术由于基因组学的快速发展，出现了更多的研究发现。但是，社会与研究成果之间的关联仍然存在争议。本文探讨了居民对基于社区的基因组研究的经验和态度。方法本研究是“城市健康促进”部分健康调查的一部分。在项目第一阶段结束时，2012年向2500名居民随机邮寄了一份自我管理的调查问卷。结果答复率为59％（n = 1477/2500）。调查结果表明，有70％的男性和50％的女性对此项目一无所知。女性和老年人更有可能了解这项研究，这表明对术语的自我评价与该项目的意识水平在统计学上相关。此外，那些了解该项目的人也意识到利用遗传信息进行研究的好处，而没有意识到的受访者，尤其是男性，则认为可能会发生意想不到的负面影响。那些对术语有较高的自我评价，并且对利用遗传信息进行研究的益处了解更高的人，对接受药物敏感性基因测试的态度更为积极，这表明女性对项目的意识和对遗传研究的关注与统计学上的相关性不高。愿意接受。结论这项研究表明，基于社区的基因组研究项目有助于提高人们对遗传研究益处的认识，但是该知识不会直接影响参与相关活动（如药物敏感性基因检测）的意愿。因此，将来必须进行其他针对风险与行动之间循环关系的研究。

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