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首页> 外文期刊>BMC Medical Genomics >The effect of unhealthy β -cells on insulin secretion in pancreatic islets
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The effect of unhealthy β -cells on insulin secretion in pancreatic islets

机译：不健康的β细胞对胰岛胰岛素分泌的影响

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Background Insulin secreted by pancreatic islet β -cells is the principal regulating hormone of glucose metabolism and plays a key role in controlling glucose level in blood. Impairment of the pancreatic islet function may cause glucose to accumulate in blood, and result in diabetes mellitus. Recent studies have shown that mitochondrial dysfunction has a strong negative effect on insulin secretion. Methods In order to study the cause of dysfunction of pancreatic islets, a multiple cell model containing healthy and unhealthy cells is proposed based on an existing single cell model. A parameter that represents the function of mitochondria is modified for unhealthy cells. A 3-D hexagonal lattice structure is used to model the spatial differences among β -cells in a pancreatic islet. The β -cells in the model are connected through direct electrical connections between neighboring β -cells. Results The simulation results show that the low ratio of total mitochondrial volume over cytoplasm volume per β -cell is a main reason that causes some mitochondria to lose their function. The results also show that the overall insulin secretion will be seriously disrupted when more than 15% of the β -cells in pancreatic islets become unhealthy. Conclusion Analysis of the model shows that the insulin secretion can be reinstated by increasing the glucokinase level. This new discovery sheds light on antidiabetic medication.
机译：背景技术胰岛β细胞分泌的胰岛素是葡萄糖代谢的主要调节激素，在控制血液中的葡萄糖水平中起着关键作用。胰岛功能受损可能导致葡萄糖在血液中积聚，并导致糖尿病。最近的研究表明，线粒体功能障碍对胰岛素分泌具有强烈的负面影响。方法为了研究胰岛功能障碍的原因，在现有单细胞模型的基础上，提出了包含健康细胞和不健康细胞的多细胞模型。对于不健康的细胞，可以修改代表线粒体功能的参数。 3-D六边形晶格结构用于模拟胰岛中β细胞之间的空间差异。模型中的β细胞通过相邻β细胞之间的直接电连接而连接。结果模拟结果表明，每个β细胞的线粒体总体积与细胞质体积之比低是导致某些线粒体丧失功能的主要原因。结果还表明，当胰岛中超过15％的β细胞变得不健康时，总体胰岛素分泌将受到严重破坏。结论对该模型的分析表明，可以通过增加葡萄糖激酶水平来恢复胰岛素分泌。这一新发现为抗糖尿病药物提供了启示。

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