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首页> 外文期刊>BMC Medical Imaging >Perfusion imaging with 320-slice spiral computed tomography and color-coded digital subtraction angiography for assessing acute skeletal muscle ischemia-reperfusion injury in a rabbit model
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Perfusion imaging with 320-slice spiral computed tomography and color-coded digital subtraction angiography for assessing acute skeletal muscle ischemia-reperfusion injury in a rabbit model

机译：用320层螺旋计算机断层扫描和彩色编码数字减影血管造影进行灌注成像，以评估兔模型中的急性骨骼肌缺血再灌注损伤

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In recent years, skeletal muscle-related ischemia-reperfusion injury (IRI) has become more common. IRI can lead to severe limb injuries, multiple organ failure, and even death in some cases. However, there is still a lack of rapid and sensitive detection methods for IRI in skeletal muscle. This study aims to explore the value of computed tomography perfusion imaging (CTPI) and color-coded digital subtraction angiography (DSA) in assessing acute IRI of skeletal muscle in a rabbit model. Fifty New Zealand white rabbits were randomly assigned to the ischemia-reperfusion (IR) group (n?=?40) or sham group (n?=?10). After 3?h of surgically-induced hindlimb ischemia, the IR group underwent reperfusion and CTPI and color-coded DSA were taken to assess the skeletal muscle at 0, 6, 12, or 24?h post-reperfusion. The data from CTPI and DSA in the right and left hindlimbs, blood flow (AF-R/L), blood volume (BV-R/L), contrast clearance rate (C-R/L) and the maximum contrast enhancement values (peak-R/L) were obtained. Serum superoxide dismutase (SOD), creatine kinase (CK), lactic dehydrogenase (LDH) and malondialdehyde (MDA) were measured. The statistical correlation between the above parameters (CTPI, color-coded DSA, and biochemical markers) was analyzed. The mean value of AF-R/L, BV-R/L, C-R/L and peak-R/L decreased linearly from 1.07?±?0.08 to 0.75?±?0.11, 1.03?±?0.06 to 0.85?±?0.14, 0.93?±?0.15 to 0.71?±?0.18, and 1.07?±?0.01 to 0.47?±?0.04, respectively. The correlation coefficients between AF-R/L and SOD, CK, LDH and MDA were 0.57, ??0.44, ??0.60, and???0.62, respectively (p??0.001). The correlation coefficients between Peak-R/L and SOD, CK, LDH, MDA were 0.59, 0.68, 0.71 and 0.66, respectively (p??0.001). The correlation coefficient between AF-R/L and Peak-R/L was 0.70 (p??0.001). Both CTPI and color-coded DSA could dynamically assess skeletal muscle IRI in rabbits.
机译：近年来，骨骼肌相关的缺血再灌注损伤（IRI）已变得更加普遍。 IRI在某些情况下可能导致严重的肢体受伤，多器官功能衰竭甚至死亡。但是，仍然缺乏快速，灵敏的骨骼肌IRI检测方法。这项研究旨在探讨计算机断层扫描灌注成像（CTPI）和彩色编码数字减影血管造影（DSA）在评估兔模型骨骼肌急性IRI中的价值。将五十只新西兰白兔随机分为缺血再灌注（IR）组（n≥40）或假组（n≥10）。手术引起的后肢缺血3小时后，对IR组进行再灌注，并在再灌注后0、6、12或24小时采用CTPI和颜色编码的DSA评估骨骼肌。来自左右后肢CTPI和DSA的数据，血流量（AF-R / L），血容量（BV-R / L），对比清除率（CR / L）和最大对比增强值（峰值R / L）。测量血清超氧化物歧化酶（SOD），肌酸激酶（CK），乳酸脱氢酶（LDH）和丙二醛（MDA）。分析了以上参数（CTPI，颜色编码的DSA和生化标记）之间的统计相关性。 AF-R / L，BV-R / L，CR / L和峰值R / L的平均值从1.07？±？0.08降至0.75？±？0.11,1.03？±？0.06降至0.85？±？ 0.14、0.93≤±0.15至0.71≤±0.18和1.07≤±0.01至0.47≤±0.04。 AF-R / L与SOD，CK，LDH和MDA之间的相关系数分别为0.57，≤0.44，≤0.60和≤0.62（p≤0.001）。峰-R / L与SOD，CK，LDH，MDA之间的相关系数分别为0.59、0.68、0.71和0.66（p≤0.001）。 AF-R / L与Peak-R / L之间的相关系数为0.70（p≤0.001）。 CTPI和彩色编码的DSA都可以动态评估兔子的骨骼肌IRI。

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