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首页> 外文期刊>BMC Ophthalmology >Acute Zonal Occult Outer Retinopathy (AZOOR): a case report of vision improvement after intravitreal injection of Ozurdex
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Acute Zonal Occult Outer Retinopathy (AZOOR): a case report of vision improvement after intravitreal injection of Ozurdex

机译：急性区域性隐匿性外部视网膜病变（AZOOR）：玻璃体内注射Ozurdex后视力改善的病例报告

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AZOOR was first described by Gass in 1993 as a syndrome with rapid loss of one or more extensive zones of the outer retinal segments. It is characterized by photopsia, minimal funduscopic changes, and electroretinographic abnormalities. The efficacy of systemic steroids in treating AZOOR has been previously described and advocated by the concept of autoimmune retinopathy. However, the use of intravitreal of sustained-released steroid had not been mentioned to date. A 34-year-old man had sudden onset of central scotoma and photopsia in the left eye. His visual acuity continued deteriorating. The visual field defect demonstrated bilateral enlarged blind spots and altitudinal defects. Fluorescein angiography (FA) showed nonspecific retinal inflammation, and an electroretinogram (ERG) illustrated decreased amplitude of the b wave in both eyes. Optical coherence tomography (OCT) examinations revealed parafoveal loss of the photoreceptor inner/outer segment (IS/OS) junction. Therefore, acute zonal occult outer retinopathy (AZOOR) was diagnosed. Although his vision did not improve under the initial treatment of systemic corticosteroid and calcium channel blocker, remarkable improvement was noticed after the intravitreal injection(IVI) of Ozurdex, consistent with the recovered IS/OS junction disruption. We herein report a typical case of AZOOR, suggesting that the intravitreal injection of steroid may benefit in certain patients.
机译：Gass于1993年首次将AZOOR描述为一种综合征，其视网膜外段的一个或多个大范围区域迅速丢失。它的特点是有活检，眼底镜改变最小和视网膜电图异常。先前已经通过自身免疫性视网膜病的概念描述和倡导了全身性类固醇治疗AZOOR的功效。但是，迄今为止尚未提及使用玻璃体内持续释放的类固醇。一名34岁的男子左眼突然出现中枢性葡萄球菌病和光斑。他的视力继续恶化。视野缺损显示双侧扩大盲点和垂直缺损。荧光素血管造影（FA）显示非特异性视网膜炎症，而视网膜电图（ERG）说明两只眼睛的b波振幅均减小。光学相干断层扫描（OCT）检查显示光感受器内/外节（IS / OS）交界处的中央凹丢失。因此，诊断为急性带状隐匿性外部视网膜病变（AZOOR）。尽管在全身性皮质类固醇和钙通道阻滞剂的初始治疗下他的视力没有改善，但是在玻璃体腔注射Ozurdex后发现明显改善，这与恢复的IS / OS连接破坏一致。我们在此报告了AZOOR的典型案例，表明玻璃体内注射类固醇可能对某些患者有益。

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