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首页> 外文期刊>BMC Family Practice >Incidence and outcome of first syncope in primary care: A retrospective cohort study
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Incidence and outcome of first syncope in primary care: A retrospective cohort study

机译：初级保健中首次晕厥的发生率和结局：一项回顾性队列研究

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Background Assessment of risk for serious cardiovascular outcome after syncope is difficult. Objectives To determine the incidence of first syncope in primary care. To investigate the relation between syncope and serious cardiovascular (CV) outcome and serious injury. Methods Retrospective cohort study using data from the Intego general practice-based registration network, collecting data from 55 general practices (90 GP's). All patients with a first syncope from 1994 to 2008 were included; five participants without syncope were matched for age and gender for every patient with syncope. The main outcome measures were incidence of first syncope by age and gender and one year risk of serious CV outcome or injury after syncope. Results 2785 patients with syncope and 13909 matched patients without syncope were included. The overall incidence of a first syncope was 1.91 per 1000 person-years (95% CI 1.83-1.98). The incidence was higher in females (2.42 (95% CI 2.32-2.55) per 1000 person-years) compared to males (1.4 (95% CI 1.32-1.49) per 1000 person-years) and follows a biphasic pattern according to age: a first peak at the age of 15-24 years is followed by a sharp rise above the age of 45. One year serious outcome after syncope was recorded in 12.3% of patients. Increasing age (HR 1.04 (1.03-1.04)), CV comorbidity (HR 3.48 (95% CI 2.48-4.90) and CV risk factors (HR 1.65 (95% CI 1.24-2.18) are associated with serious outcome. Cox regression, adjusting for age, gender, CV comorbidity and risk factors, showed that syncope was an independent risk factor for serious CV outcome or injury (HR 3.99 (95% CI 3.44-4.63)). The other independent risk factors were CV comorbidity (HR 1.81 (95% CI 1.51-2.17)) and age (HR 1.03 (95% CI 1.03-1.04)). Conclusions Incidence rate of first syncope in primary care was 1.91 per 1000 person-years. One year risk of serious outcome after syncope was 12.3%. Increasing age, CV comorbidity and risk factors are associated with serious outcome. Compared to a control group, syncope on itself is an independent risk factor for serious outcome (adjusted for age, gender, CV comorbidity and risk factors).
机译：背景晕厥后评估严重心血管结局的风险非常困难。目的确定初级晕厥在初级保健中的发生率。调查晕厥与严重心血管（CV）结果和严重伤害之间的关系。方法回顾性队列研究使用来自基于Intego通用实践的注册网络的数据，收集来自55个通用实践（90个GP）的数据。纳入所有1994年至2008年初发晕厥的患者。每位晕厥患者的五名无晕厥的参与者的年龄和性别均匹配。主要结局指标是按年龄和性别划分的首次晕厥发生率，以及晕厥后发生严重CV结局或受伤的一年风险。结果纳入2785例晕厥患者和13909例无晕厥匹配患者。第一次晕厥的总发生率是每1000人年1.91（95％CI 1.83-1.98）。女性（每千人年2.42（95％CI 2.32-2.55）每千人年的发生率高于男性（每千人年1.4（95％CI 1.32-1.49）每千人年），并且根据年龄呈双相分布：在15-24岁时首次出现高峰，随后在45岁以上急剧上升。记录为晕厥后一年的严重预后为12.3％的患者。年龄增长（HR 1.04（1.03-1.04）），CV合并症（HR 3.48（95％CI 2.48-4.90）和CV危险因素（HR 1.65（95％CI 1.24-2.18））与严重结局相关。Cox回归，调整年龄，性别，心血管合并症和危险因素的研究表明，晕厥是严重心血管结果或损伤的独立危险因素（HR 3.99（95％CI 3.44-4.63））;其他独立危险因素是CV合并症（HR 1.81（结论：95％CI（1.51-2.17））和年龄（HR 1.03（95％CI 1.03-1.04））。结论初级晕厥在初级保健中的发生率为1.91 / 1000人年，晕厥后一年发生严重结局的风险为12.3。年龄，心血管合并症和危险因素的增加与严重后果相关，与对照组相比，晕厥本身是严重后果的独立危险因素（根据年龄，性别，心血管合并症和危险因素进行调整）。

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