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首页> 外文期刊>BMC Gastroenterology >A preliminary investigation on single nucleotide polymorphism rs2287622 of bile salt export pump gene in patients with chronic hepatitis C virus infection in Hunan, China
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A preliminary investigation on single nucleotide polymorphism rs2287622 of bile salt export pump gene in patients with chronic hepatitis C virus infection in Hunan, China

机译：湖南省慢性丙型肝炎病毒感染者胆汁盐输出泵基因单核苷酸多态性rs2287622的初步研究

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Background European researchers have underscored associations between single nucleotide polymorphism (SNP) rs2287622 of the hepatobiliary bile salt export pump (BSEP) gene and the risk of hepatitis C virus (HCV) infection. The distributions of SNP rs2287622 are racially specific. This study was aimed to preliminarily investigate the distribution of BSEP gene SNP rs2287622 in the Han patients with chronic HCV-infection (CHC) in Hunan, China. Methods BSEP gene SNP rs2287622 of 165 CHC patients, 99 patients with chronic hepatitis B virus infection (CHB) and 99 healthy individuals were analyzed by polymerase chain reaction-restriction fragment length polymorphism analysis and nucleotide sequencing. Results The overall frequencies of the C allele of BESP gene SNP rs2287622 in the CHC patients, CHB patients and healthy individuals were 74.2, 72.7 and 74.2%, respectively ( P >?0.05). The overall odds ratios (ORs) aiming at predicting CHC risk by comparing the ratios of the frequency distribution of alleles or genotypes in the CHC group with those in the non-CHC group had no statistical significance ( P >?0.05). However, the CHC ORs of CC vs TT, TC vs TT and CC?+?CT vs TT among the individuals aged over 40?years were 2.680, 3.122 and 2.824 respectively ( P Conclusions Among the Han individuals aged over 40?years in Hunan, China, genotype CC or CT of BSEP gene SNP rs2287622 may correlate with higher risk of CHC in comparison with genotype TT. Further study with a larger cohort is essential.
机译：背景技术欧洲研究人员强调了肝胆汁盐输出泵（BSEP）基因的单核苷酸多态性（SNP）rs2287622与丙型肝炎病毒（HCV）感染风险之间的关联。 SNP rs2287622的分布是种族特定的。本研究旨在初步研究中国湖南省汉族慢性HCV感染（CHC）患者中BSEP基因SNP rs2287622的分布。方法采用聚合酶链反应-限制性片段长度多态性分析和核苷酸测序技术对165例CHC患者，99例慢性乙型肝炎病毒感染者和99例健康人的BSEP基因SNP rs2287622进行分析。结果CHSP患者，CHB患者和健康个体中BESP基因SNP rs2287622的C等位基因总频率分别为74.2％，72.7％和74.2％（P> 0.05）。通过比较CHC组与非CHC组中等位基因或基因型频率分布的比率来预测CHC风险的总比值比（OR）无统计学意义（P>？0.05）。但40岁以上人群CC，TT，TC，TT和CC？+？CT，TT的CHC OR分别为2.680、3.122和2.824（P结论：湖南40岁以上汉族人群）与TT基因型相比，中国的BSEP基因SNP rs2287622的CC型或CT基因型可能与CHC风险更高有关，因此有必要对更大的队列进行进一步研究。

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