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首页> 外文期刊>BMC Urology >Dissection of the inferior mesenteric vein versus of the inferior mesenteric artery for the genitourinary function after laparoscopic approach of rectal cancer surgery: a randomized controlled trial
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Dissection of the inferior mesenteric vein versus of the inferior mesenteric artery for the genitourinary function after laparoscopic approach of rectal cancer surgery: a randomized controlled trial

机译：腹腔镜直肠癌手术后泌尿生殖系统功能的剖析肠系膜下静脉与肠系膜下动脉：一项随机对照试验

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Total Mesorectal Excision (TME) is the standard surgical technique for the treatment of rectal cancer. However, rates of sexual dysfunction ofup to 50% have been described after TME, and rates of urinary dysfunction of up to 30%. Although other factors are involved, the main cause of postoperative genitourinary dysfunction is intraoperative injury to the pelvic autonomic nerves. The risk is particularly high in the inferior mesenteric artery (IMA). The aim of this study is to compare pre- and post-TME sexual dysfunction, depending on the surgical approach usedin the inferior mesenteric vessels: either directly on the IMA, or from the inferior mesenteric vein (IMV) to the IMA. Prospective, randomized,controlled study of patients with rectal adenocarcinoma with neoadjuvant chemoradiotherapy, who will be randomly assigned to one of two groups depending on the surgical approach to the inferior mesenteric vessels. The main variable is pre- and postoperative sexual dysfunction; secondary variables are visualization and preservation of the pelvic autonomic nerves, pre- and postoperative urinary dysfunction, and pre- and postoperative quality of life. The sample will comprise 90 patients, 45 per group. The aim is to demonstrate that the dissection route from the IMV towards the IMA favors the preservation of the pelvic autonomic nerves and thus reducesrates of sexual dysfunction post-surgery. Ethical and Clinical Research Committee, Parc Taulí University Hospital: ID 017/315. ClinicalTrials.gov TAU-RECTALNERV-PRESERV-2018 (TRN: NCT03520088 ) (Date of registration 04/03/2018).
机译：全直肠系膜切除术（TME）是用于治疗直肠癌的标准手术技术。然而，已经描述了TME后性功能障碍的发生率高达50％，而尿功能障碍的发生率高达30％。尽管涉及其他因素，但术后泌尿生殖道功能障碍的主要原因是盆腔自主神经的术中损伤。肠系膜下动脉（IMA）的风险特别高。这项研究的目的是比较TME前后的性功能障碍，具体取决于肠系膜下血管所使用的手术方法：直接在IMA上，或者从肠系膜下静脉（IMV）到IMA。直肠腺癌患者接受新辅助放化疗的前瞻性，随机，对照研究将根据下肠系膜血管的手术方法随机分为两组。主要变量是手术前后的性功能障碍。次要变量是骨盆自主神经的可视化和保存，术前和术后尿功能障碍以及术前和术后生活质量。样本将包括90名患者，每组45名。目的是证明从IMV到IMA的解剖路径有利于保留盆腔自主神经，从而减少术后性功能障碍的发生率。塔利大学公园医院伦理与临床研究委员会：ID 017/315。 ClinicalTrials.gov TAU-RECTALNERV-PRESERV-2018（TRN：NCT03520088）（注册日期04/03/2018）。

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