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首页> 外文期刊>BMC Urology >Is there any association between prostate-specific antigen screening frequency and uptake of active surveillance in men with low or very low risk prostate cancer?
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Is there any association between prostate-specific antigen screening frequency and uptake of active surveillance in men with low or very low risk prostate cancer?

机译：在具有低风险或极低风险的前列腺癌男性中，前列腺特异性抗原筛查频率与主动监测的摄取之间是否存在关联？

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Patient-related factors such as concern about cancer are believed to influence both men’s decisions to undergo prostate specific antigen (PSA) testing and to have definitive treatment if diagnosed with low risk prostate cancer (PCa). The potential link between screening frequency and choice of active surveillance (AS) for low risk disease has not been studied previously. Our aim was to investigate whether there is any association between PCa screening frequency or previous negative prostate biopsy and uptake of AS among men with low risk PCa. This register-based study included all men ≤75?years from Stockholm who were diagnosed with low risk PCa from 2008 to 2014 (n?=?4336). Pre-diagnostic PSA testing and biopsy histories were obtained from the Stockholm PSA and Biopsy Register, a population-based register for the Stockholm country. The association between previous screening/biopsy history and AS uptake (based on primary treatment recorded in the National Prostate Cancer Register) was examined using multivariable logistic regression. Forty seven percent of men with low risk PCa underwent AS. Uptake was associated with older age, very low risk disease, more recent diagnosis and absence of family history. None of the screening/biopsy measures (testing frequency, mean interval, PSA velocity, highest pre-diagnostic PSA or prior negative biopsy) were associated with uptake of AS among men with low risk PCa. Generalisability to settings with different policies and practices may be limited. We found no evidence that screening frequency and negative biopsy influence uptake of AS among Swedish men with low risk PCa. Further research is required to determine factors that still present barriers for men taking up AS.
机译：人们认为，与患者有关的因素（例如对癌症的担忧）会影响男性接受前列腺特异性抗原（PSA）测试的决定，并且如果被诊断出患有低风险前列腺癌（PCa），则将进行最终治疗。先前尚未研究过筛查频率与低风险疾病主动监测（AS）选择之间的潜在联系。我们的目的是调查低风险PCa男性中PCa筛查频率或先前的阴性前列腺活检与AS摄取之间是否存在关联。这项基于登记的研究包括了从斯德哥尔摩到2008年至2014年被诊断出患有低风险PCa的所有年龄≤75岁的男性（n = 4336）。从斯德哥尔摩PSA和活检登记册获得了诊断前的PSA测试和活检历史记录，该登记册是斯德哥尔摩国家的基于人口的登记册。使用多变量逻辑回归分析检查先前的筛查/活检史与AS摄取之间的关联（基于美国国家前列腺癌登记簿中记录的主要治疗）。低风险PCa的男性中有47％接受了AS。摄取与年龄较大，极低风险的疾病，较新的诊断和无家族史有关。筛查/活检指标（测试频率，平均间隔，PSA速度，最高的诊断前PSA或先前的阴性活检）与低风险PCa男性摄取AS无关。具有不同策略和实践的设置的通用性可能会受到限制。我们没有发现证据表明筛查频率和活检阴性会影响瑞典低危PCa男性的AS摄取。需要进一步的研究来确定仍然构成男性服用AS障碍的因素。

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