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The impact of non-responders on health and lifestyle outcomes in an intervention study

机译：干预研究中无反应者对健康和生活方式结果的影响

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Background A randomized intervention study, “Preventive consultations for 20- to 40-year-old young adults”, investigated whether preventive consultations with a general practitioner could help young adults with multiple psychosocial and lifestyle problems to change health behavior. To optimize the response rate of questionnaires at 1?year post-intervention, the non-responders were reminded by telephone. The aim of this study was to examine potential selection bias induced by non-response by comparing responder and non-responder populations at baseline, and to examine the impact on outcomes by comparing initial respondents to respondents after telephone reminding. Method Non-responders were compared with primary responders using logistic regression models that included socio-demographic factors, health-related factors, and variables related to the intervention study. In order to describe the impact of including responders after telephone reminding on the intervention’s effect on different health, resource, and lifestyle outcomes, we compared results in models including and excluding responders after telephone reminding. Results Telephone contact raised the response by 10% from 316 (64%) to 364 (74%) among young adults with multiple problems. Being male was the only factor that significantly predicted non-response in the model after adjustment for other variables. The responders after telephone reminding tended to improve health and lifestyle more than the primary responders, but not significantly so. Although the additional responses did not change the estimates of the 1-year effect on health and lifestyle changes, it contributed to increased precision of the results. Conclusion Even though the population of primary non-responders had to some degree a different composition than the primary responders, inclusion of responders after telephone reminding did not significantly change the estimates for effect at the 1-year follow-up; however, the additional responses increased the precision of the estimates. Trial registration ClinicalTrials.gov: NCT01231256
机译：背景技术一项随机干预研究“为20至40岁的年轻人进行预防性咨询”，调查了​​与全科医生的预防性咨询是否可以帮助患有多种社会心理和生活方式问题的年轻人改变健康行为。为了优化干预后1年的问卷答复率，通过电话提醒未答复者。这项研究的目的是通过比较基线时的响应者和非响应者群体来检查由非响应引起的潜在选择偏见，并通过在电话提醒后将初始受访者与受访者进行比较来检验对结果的影响。方法采用逻辑回归模型将非应答者与主要应答者进行比较，该模型包括社会人口统计学因素，健康相关因素以及与干预研究相关的变量。为了描述在电话提醒后包括响应者对干预措施对不同健康，资源和生活方式结果的影响的影响，我们比较了在电话提醒后包括和排除响应者的模型中的结果。结果电话联系使有多种问题的年轻人的应答率从316（64％）上升了10％，达到364（74％）。调整其他变量后，男性是唯一能显着预测模型无反应的因素。电话提醒后的响应者倾向于改善健康状况和生活方式，而不是主要响应者，但并非明显。尽管额外的答复并没有改变对健康和生活方式变化对1年影响的估计，但它有助于提高结果的准确性。结论尽管主要的无反应者群体在某种程度上与主要的反应者组成不同，但电话提醒后纳入反应者并没有显着改变对1年随访的效果估计。但是，额外的答复增加了估计的准确性。试用注册ClinicalTrials.gov：NCT01231256

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