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首页> 外文期刊>BMC Pulmonary Medicine >Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study
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Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study

机译：自膨胀金属支架在气管支气管良性狭窄中的长期随访：一项回顾性研究

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Self-expandable metallic stents (SEMSs) have enabled a approving management of malignant airway stenosis. However, the long-term efficacy and safety of this treatment in patients with benign airway stricture are unclear. We conducted this study to retrospectively determine the efficacy and long-term outcomes in patients who have undergone SEMS placement for benign tracheobronchial stenosis. All patients treated with SEMSs from July 2003 to June 2016 were reviewed for symptomatic response, complications, and long-term outcomes. Total 131 stents were successfully deployed in 116 patients. Ninety-eight patients demonstrated clinical improvement after stent insertion (84.48%; 95% confidence interval [CI]: 77.89–91.07). Compared with uncovered stents, covered stents were associated with more sore throats complaints or chest pain (13.89% versus 28.81%, P?=?0.036) and with higher incidences of major and minor granulation tissue formation and with recurrent stenosis (4.17% versus 15.25%, P?=?0.029; 11.11% versus 37.29%, P??0.0001 and 9.72% versus 28.81%, P?=?0.005, respectively). Each covered and uncovered stent developing tissue hyperplasia required a median of 2 (range: 1–15) and 1(range: 1–7) fibrobronchoscope with electrocautery therapy, respectively. At follow-up (median: 1276?days; range: 2–4263), 68 patients had complete resolution, 15 remained under interventional treatment, 8 had bronchial occlusions, 7 underwent surgery, 14 were lost to follow-up, and 4 died of stent unrelated causes. SEMS placement achieved most clinical improvement among patients in our study, if adequate endotracheal measures were used to address stent-related complications. The use of permanent SEMSs for benign tracheobronchial stenosis was effective and safe for the majority of patients in a long-term follow-up. The study has been retrospectively registered in the China Clinical Trial Registry on October 21, 2018 (Registry ID: ChiCTR1800019024 ).
机译：自膨胀金属支架（SEMSs）已批准批准管理恶性气道狭窄。但是，这种治疗对气道良性狭窄患者的长期疗效和安全性尚不清楚。我们进行了这项研究，以回顾性确定在接受针对良性气管支气管狭窄的SEMS放置的患者中的疗效和长期疗效。从2003年7月至2016年6月，所有接受SEMS治疗的患者均进行了症状缓解，并发症和长期预后评估。共有131个支架成功部署在116例患者中。 98例患者在支架置入后表现出临床改善（84.48％; 95％置信区间[CI]：77.89–91.07）。与未覆盖的支架相比，有盖支架与更多的咽喉不适或胸痛有关（13.89％比28.81％，P <= 0.036），并且主要和次要的肉芽组织形成和狭窄的发生率更高（4.17％比15.25）。 ％，P 1 ＝ 0.029; 11.11％对37.29％，P 2 ＜0.0001和9.72％对28.81％，P 2 ＝ 0.005）。进行电灼治疗的每个覆盖的和未覆盖的发展组织增生的支架分别需要中位数2（范围：1-15）和1（范围：1-7）的纤维支气管镜。随访时（中位数：1276天;范围：2–4263），68例患者完全消退，15例接受介入治疗，8例支气管阻塞，7例接受手术，14例失访，4例死亡支架无关的原因。如果采用足够的气管内措施来解决支架相关并发症，则SEMS植入可在本研究患者中取得最大的临床改善。在长期随访中，永久性SEMS对良性气管支气管狭窄的使用对大多数患者都是有效且安全的。该研究已于2018年10月21日在中国临床试验注册中心进行回顾性注册（注册号：ChiCTR1800019024）。

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