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首页> 外文期刊>BMC Pulmonary Medicine >Hemoptysis requiring bronchial artery embolization in patients with nontuberculous mycobacterial lung disease
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Hemoptysis requiring bronchial artery embolization in patients with nontuberculous mycobacterial lung disease

机译：非结核分枝杆菌性肺病患者需要支气管动脉栓塞的咯血

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Although infections caused by nontuberculous mycobacteria (NTM) are increasing in prevalence, there are few data about hemoptysis in patients with NTM lung disease. This study investigated the characteristics and prognosis of hemoptysis secondary to NTM infection. Following a retrospective review of cases managed between 2006 and 2016, 183 patients with NTM lung disease were enrolled and analyzed. Among 183 patients with NTM lung disease, Mycobacterium intracellulare (n?=?64, 35%) was the major cause of NTM infection, followed by M. avium (n?=?59, 32.2%) and M. abscessus complex (n?=?40, 21.9%). Hemoptysis developed in 78 patients (42.6%), among whom 33 (42.3%) required bronchial artery embolization (BAE). Between patients with and without hemoptysis, there were no significant differences with respect to sex, radiographic manifestations, distribution over 3 lobes on chest computed tomography, history of pulmonary tuberculosis, antiplatelet or anticoagulation therapy, and species of NTM. However, mean age at diagnosis was significantly lower in the hemoptysis group in univariate and multivariate analyses (65.7?±?12.8 vs. 59.7?±?11.8, P?=?0.002, odds ratio: 0.969, 95% confidence interval: 0.944–0.996). Among patients with hemoptysis, those requiring medical therapy and those requiring BAE were not significantly different in terms of demographic characteristics, radiographic manifestations, and distribution over 3 lobes. All patients who received BAE showed immediate clinical improvement, no procedure-related complications, and none of them died during the period under review. NTM lung disease patients commonly experienced hemoptysis without specific risk factors except for relatively young age. Although some patients with hemoptysis needed BAE, the success rate of BAE was high, and there were no serious complications associated with BAE.
机译：尽管由非结核分枝杆菌（NTM）引起的感染正在增加，但是关于NTM肺病患者咯血的数据很少。本研究调查了NTM感染继发咯血的特征和预后。在对2006年至2016年间管理的病例进行回顾性研究后，纳入并分析了183例NTM肺病患者。在183例NTM肺部疾病患者中，胞内分枝杆菌（n？=？64，35％）是NTM感染的主要原因，其次是鸟分枝杆菌（n？=？59，32.2％）和脓肿分支杆菌（n。 =＝？40，21.9％）。咯血发生在78例患者中（42.6％），其中33例（42.3％）需要支气管动脉栓塞（BAE）。在有和没有咯血的患者之间，性别，放射学表现，胸部计算机断层扫描的3个叶分布，肺结核病史，抗血小板或抗凝治疗以及NTM种类之间无显着差异。然而，在单因素和多因素分析中，咯血组的诊断平均年龄显着降低（65.7±±12.8 vs. 59.7±±11.8，P≥0.002，优势比：0.969，95％置信区间：0.944– 0.996）。在咯血患者中，需要药物治疗的患者和需要BAE的患者在人口统计学特征，放射学表现和3个叶的分布方面无显着差异。所有接受BAE的患者均表现出立即的临床改善，无与手术相关的并发症，并且在本报告所述期间均无死亡。除相对年轻的年龄外，NTM肺病患者通常经历咯血而没有特定的危险因素。尽管有些咯血患者需要BAE，但是BAE的成功率很高，并且没有与BAE相关的严重并发症。

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