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首页> 外文期刊>BMC Pulmonary Medicine >Determination of respiratory gas flow by electrical impedance tomography in an animal model of mechanical ventilation
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Determination of respiratory gas flow by electrical impedance tomography in an animal model of mechanical ventilation

机译：在机械通气动物模型中通过电阻抗层析成像确定呼吸气体的流量

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Background A recent method determines regional gas flow of the lung by electrical impedance tomography (EIT). The aim of this study is to show the applicability of this method in a porcine model of mechanical ventilation in healthy and diseased lungs. Our primary hypothesis is that global gas flow measured by EIT can be correlated with spirometry. Our secondary hypothesis is that regional analysis of respiratory gas flow delivers physiologically meaningful results. Methods In two sets of experiments n?=?7 healthy pigs and n?=?6 pigs before and after induction of lavage lung injury were investigated. EIT of the lung and spirometry were registered synchronously during ongoing mechanical ventilation. In-vivo aeration of the lung was analysed in four regions-of-interest (ROI) by EIT: 1) global, 2) ventral (non-dependent), 3) middle and 4) dorsal (dependent) ROI. Respiratory gas flow was calculated by the first derivative of the regional aeration curve. Four phases of the respiratory cycle were discriminated. They delivered peak and late inspiratory and expiratory gas flow (PIF, LIF, PEF, LEF) characterizing early or late inspiration or expiration. Results Linear regression analysis of EIT and spirometry in healthy pigs revealed a very good correlation measuring peak flow and a good correlation detecting late flow. PIFEIT?=?0.702?·?PIFspiro?+?117.4, r2?=?0.809; PEFEIT?=?0.690?·?PEFspiro-124.2, r2?=?0.760; LIFEIT?=?0.909?·?LIFspiro?+?27.32, r2?=?0.572 and LEFEIT?=?0.858?·?LEFspiro-10.94, r2?=?0.647. EIT derived absolute gas flow was generally smaller than data from spirometry. Regional gas flow was distributed heterogeneously during different phases of the respiratory cycle. But, the regional distribution of gas flow stayed stable during different ventilator settings. Moderate lung injury changed the regional pattern of gas flow. Conclusions We conclude that the presented method is able to determine global respiratory gas flow of the lung in different phases of the respiratory cycle. Additionally, it delivers meaningful insight into regional pulmonary characteristics, i.e. the regional ability of the lung to take up and to release air.
机译：背景技术最近的一种方法是通过电阻抗断层扫描（EIT）来确定肺的局部气流。这项研究的目的是证明该方法在健康和患病肺部机械通气的猪模型中的适用性。我们的主要假设是，通过EIT测量的总体气体流量可以与肺活量测定法相关。我们的第二个假设是，对呼吸气流的区域分析可提供具有生理意义的结果。方法在两组实验中，分别对诱导灌洗性肺损伤前后的n = 7的健康猪和n = 6的猪进行了研究。正在进行的机械通气期间，肺的EIT和肺活量测定同步记录。通过EIT在四个感兴趣区域（ROI）中对肺的体内通气进行了分析：1）整体，2）腹侧（非依赖性），3）中部和4）背侧（依赖性）ROI。通过区域曝气曲线的一阶导数计算呼吸气体流量。区分了呼吸循环的四个阶段。他们提供了高峰和晚期吸气和呼气气流（PIF，LIF，PEF，LEF），以早期或晚期吸气或呼气为特征。结果健康猪的EIT和肺活量测定的线性回归分析显示，测量峰值流量与检测后期流量的相关性非常好。 PIF EIT ？=？0.702？·？PIF spiro ？+？117.4，r 2 ？=？0.809; PEF EIT ？=？0.690？·？PEF spiro -124.2，r 2 ？=？0.760; LIF EIT ？=？0.909？·？LIF spiro ？+？27.32，r 2 ？=？0.572和LEF EIT < /sub>?=?0.858?·?LEFspiro-10.94，r 2 ？=？0.647。 EIT得出的绝对气体流量通常小于肺活量测定仪的数据。在呼吸周期的不同阶段，区域气流分布不均。但是，在不同的呼吸机设置下，气流的区域分布保持稳定。中度肺损伤改变了气流的区域模式。结论我们得出的结论是，所提出的方法能够确定呼吸周期不同阶段中的整体呼吸气体流量。另外，它提供了对区域肺部特征的有意义的洞察力，即肺部吸收和释放空气的区域能力。

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