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首页> 外文期刊>BMC Anesthesiology >Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model
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Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model

机译：先发性神经周围布比卡因可减轻大鼠脊髓神经结扎模型中机械性和冷性异常性疼痛的维持

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Background Neuropathic pain is evasive to treat once developed, however evidence suggests that local administration of anesthetics near the time of injury reduces the development of neuropathic pain. As abnormal electrical signaling in the damaged nerve contributes to the initiation and maintenance of neuropathic pain, local administration of anesthetics prior to injury may reduce its development. We hypothesized that local treatment with bupivacaine prior to nerve injury in a rat model of spinal nerve ligation (SNL) would attenuate the initiation and/or maintenance of neuropathic pain behaviors. Methods On the day prior to SNL, baseline measures of pre-injury mechanical, thermal, and/or cold sensitivity were recorded in adult male Sprague–Dawley rats. Immediately prior to SNL or sham treatment, the right L5 nerve was perineurally bathed in either 0.05?mL bupivacaine (0.5?%) or sterile saline (0.9?%) for 30?min. Mechanical allodynia, thermal hyperalgesia, and/or cold allodynia were then examined at 3, 7, 10, 14 and 21?days following SNL. Results Rats exhibited both mechanical and cold allodynia, but not thermal hyperalgesia, within 3?days and up to 21?days post-SNL. No significant pain behaviors were observed in sham controls. Preemptive local bupivacaine significantly attenuated both mechanical and cold allodynia as early as 10?days following SNL compared to saline controls and were not significantly different from sham controls. Conclusions These data indicate that local treatment with bupivacaine prior to surgical manipulations that are known to cause nerve damage may protect against the maintenance of chronic neuropathic pain.
机译：背景技术一旦发生神经病性疼痛，就可以逃避治疗，但是有证据表明，在受伤时局部使用麻醉药可以减轻神经性疼痛的发生。由于受损神经中异常的电信号传导有助于神经性疼痛的发生和维持，因此在损伤前局部使用麻醉药可能会减少其发展。我们假设在脊髓神经结扎（SNL）大鼠模型中，在神经损伤之前用布比卡因进行局部治疗会减弱神经性疼痛行为的发生和/或维持。方法在SNL的前一天，记录成年雄性Sprague–Dawley大鼠损伤前机械，热和/或冷敏感性的基线测量值。在SNL或假手术治疗之前，立即将右L5神经在神经周围浸入0.05？mL布比卡因（0.5？％）或无菌盐水（0.9？％）中30分钟。然后在SNL后第3、7、10、14和21天检查机械性异常性疼痛，热痛觉过敏和/或冷性异常性疼痛。结果大鼠在SNL后3天内至21天内均显示出机械性和冷性异常性疼痛，但未出现热痛觉过敏。在假对照中未观察到明显的疼痛行为。与生理盐水对照组相比，抢先局部布比卡因最早在SNL后10天可显着减弱机械性和冷性异常性疼痛，与假对照组无明显差异。结论这些数据表明，在已知引起神经损伤的外科手术之前用布比卡因进行局部治疗可预防慢性神经性疼痛的维持。

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