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Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements

机译:生物炎症标记物介导术前疼痛相关行为对术后镇痛药需求的影响

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The predictive value of an individual’s attitude towards painful situations and the status of his immune system for postoperative analgesic requirements are not well understood. These may help the clinician to anticipate individual patient’s needs. Sixty patients, who underwent a laparoscopic cholecystectomy under standardised general anaesthesia, were included. The total analgesic requirements during the first 48?h were the primary endpoint (unitary dosage, UD). The individual’s attitude towards imaginary painful situations was measured with the Situational Pain Scale (SPS). The emotional status was assessed by the Hospital Anxiety and Depression Scale (HADS) and the inflammatory status by the neutrophil-to-lymphocyte ratio (NLR). Univariate analyses revealed a significant association between UD and SPS, HADS and NLR. A negative relationship between SPS and NLR (NLR?=?0.820–0.180*SPS;R2?=?0.211;P?
机译:人们对疼痛状况的态度及其免疫系统状况对术后镇痛要求的预测价值尚不十分清楚。这些可以帮助临床医生预测每个患者的需求。包括60例在标准全身麻醉下进行了腹腔镜胆囊切除术的患者。在最初48小时内的总镇痛要求为主要终点(统一剂量,UD)。个人对想象中的痛苦情况的态度是通过情境疼痛量表(SPS)来衡量的。通过医院焦虑和抑郁量表(HADS)评估情绪状态,通过中性粒细胞与淋巴细胞比(NLR)评估炎症状态。单变量分析显示UD和SPS,HADS和NLR之间存在显着关联。 SPS和NLR之间呈负相关(NLR?=?0.820-0.180 * SPS; R2?=?0.211; P?<?0.001)和SPS与HADS之间呈正相关(HADS?=?14.8?+?1.63 * SPS ;观察到R 2 = 0.159; P 2 = 0.002。多元线性回归分析表明,NLR对UD的贡献最有效。调解分析显示,通过NLR(SPS在NLR上的RPS:R2α=?0.211; P?=α<0.001),SPS对UD的影响得到了完全的调解(R2?=?0.103; P?=?0.012), HADS(HADS上的SPS:R2≥0.159;P≥0.002)。 SPS解释的UD差异是间接的,通过NLR达到46%,通过HADS达到34%。在这个系列中,术前疼痛相关的态度(SPS)与胆囊切除术后的镇痛要求(UD)相关。这种影响的百分之八十是由HADS和NLR介导的。

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