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首页> 外文期刊>BMC Infectious Diseases >Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes
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Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes

机译：化脓性链球菌的侵入性emm3 / ST15菌株的传播引起的链球菌中毒性休克综合征

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Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular epidemiology analysis has suggested that the frequency of emm3 GAS has been recently increasing. A 14-year-old patient was diagnosed with streptococcal toxic shock syndrome and severe pneumonia, impaired renal function, and rhabdomyolysis. GAS was isolated from a culture of endotracheal aspirates and designated as KS030. Comparative genome analysis suggested that KS030 is classified as emm3 (emm-type) and ST15 (multilocus sequencing typing [MLST]), which is similar to iGAS isolates identified in the UK (2013) and Switzerland (2015). We conclude that the global dissemination of emm3/ST15 GAS strain has the potential to cause invasive disease.
机译：化脓性链球菌（A群链球菌[GAS]）是引起多种临床表现的主要人类病原体。尽管侵入性GAS（iGAS）感染相对不常见，但emm3 / ST15 GAS是一种高毒力，侵入性和致病性菌株。全球分子流行病学分析表明，emm3 GAS的频率最近一直在增加。一名14岁的患者被诊断患有链球菌中毒性休克综合征和严重的肺炎，肾功能受损和横纹肌溶解症。从气管内吸出物的培养物中分离出GAS，命名为KS030。比较基因组分析表明，KS030被分类为emm3（emm型）和ST15（多基因座测序类型[MLST]），类似于在英国（2013年）和瑞士（2015年）鉴定的iGAS分离株。我们得出的结论是，全球传播emm3 / ST15 GAS菌株具有引起侵袭性疾病的潜力。

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