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首页> 外文期刊>Brain Sciences >In Search of Sleep Biomarkers of Alzheimer’s Disease: K-Complexes Do Not Discriminate between Patients with Mild Cognitive Impairment and Healthy Controls
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In Search of Sleep Biomarkers of Alzheimer’s Disease: K-Complexes Do Not Discriminate between Patients with Mild Cognitive Impairment and Healthy Controls

机译：寻找阿尔茨海默氏病的睡眠生物标志物：K复杂度不能区分轻度认知障碍患者和健康对照者

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摘要

The K-complex (KC) is one of the hallmarks of Non-Rapid Eye Movement (NREM) sleep. Recent observations point to a drastic decrease of spontaneous KCs in Alzheimer’s disease (AD). However, no study has investigated when, in the development of AD, this phenomenon starts. The assessment of KC density in mild cognitive impairment (MCI), a clinical condition considered a possible transitional stage between normal cognitive function and probable AD, is still lacking. The aim of the present study was to compare KC density in AD/MCI patients and healthy controls (HCs), also assessing the relationship between KC density and cognitive decline. Twenty amnesic MCI patients underwent a polysomnographic recording of a nocturnal sleep. Their data were compared to those of previously recorded 20 HCs and 20 AD patients. KCs during stage 2 NREM sleep were visually identified and KC densities of the three groups were compared. AD patients showed a significant KC density decrease compared with MCI patients and HCs, while no differences were observed between MCI patients and HCs. KC density was positively correlated with Mini-Mental State Examination (MMSE) scores. Our results point to the existence of an alteration of KC density only in a full-blown phase of AD, which was not observable in the early stage of the pathology (MCI), but linked with cognitive deterioration.
机译：K复合体（KC）是非快速眼动（NREM）睡眠的标志之一。最近的观察表明，阿尔茨海默氏病（AD）中自发性KC急剧下降。然而，尚无研究调查这种现象在AD的发展中何时开始。仍缺乏对轻度认知障碍（MCI）中的KC密度的评估，轻度认知障碍（MCI）被认为是正常认知功能和可能的AD之间可能的过渡阶段。本研究的目的是比较AD / MCI患者和健康对照（HCs）中的KC密度，并评估KC密度与认知能力下降之间的关系。多发性睡眠记忆MCI遗忘症患者的夜间睡眠。将他们的数据与先前记录的20位HC和20位AD患者的数据进行比较。视觉识别第2阶段NREM睡眠期间的KC，并比较三组的KC密度。与MCI患者和HC相比，AD患者的KC密度显着降低，而MCI患者和HC之间无差异。 KC密度与小精神状态检查（MMSE）得分呈正相关。我们的结果指出，仅在AD的成熟阶段，KC密度才会改变，这在病理学（MCI）的早期阶段无法观察到，但与认知能力下降有关。

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