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首页> 外文期刊>Brazilian Journal of Infectious Diseases >HLA profile in patients with AIDS and tuberculosis
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HLA profile in patients with AIDS and tuberculosis

机译：艾滋病和结核病患者的HLA谱

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Studies carried out in various populations have reported an association between some HLA specificities and susceptibility to tuberculosis. We investigated the class I and class II HLA profile in Brazilian patients of various ethnic backgrounds who had AIDS and tuberculosis. Twenty-two adult patients with AIDS and tuberculosis (Group I), 103 patients with AIDS without tuberculosis (Group II) and 423 healthy individuals not infected with HIV (Group III) were evaluated. Diagnosis of HIV infection was made by ELISA, confirmed by a gelatin particle agglutination test. Diagnosis of tuberculosis was made based on clinical/radiological presentation and direct bacilloscopy or clinical specimen cultures. Class I antigens were typed by microlymphotoxicity. Class II alleles were characterized by the polymerase chain reaction (PCR). Differences in frequency of HLA specificities between groups were found in the following antigens/alleles: Group I x Group II: HLA-A31 - p=0.026; HLA-B41 - p= 0.037; HLA-DRB1*10 - p=0.037; HLA-DQB1*5 - p=0.009. Group I x Group III (control): HLA-A31 - p = 0.000008; odds ratio (OR)=31.75; HLA-B41 - p=0.003; HLA-DQB1*5 - p=0.02. HLA-A31 and HLA-B41 antigens and the HLA-DRB1*10 and HLA-DQB1*05 alleles were over-represented in patients with AIDS and tuberculosis (Group I), suggesting that these HLA molecules are associated with susceptibility to tuberculosis in Brazilian patients with AIDS.
机译：在各种人群中进行的研究报告了一些HLA特异性与结核病易感性之间的关联。我们调查了患有艾滋病和结核病的各种种族背景的巴西患者的I类和II类HLA谱。对22名艾滋病和结核病成年患者（第I组），103例无结核艾滋病（第II组）和423名未感染HIV的健康个体（第III组）进行了评估。通过明胶颗粒凝集试验证实了通过ELISA对HIV感染的诊断。结核病的诊断是根据临床/放射学表现和直接的细菌学检查或临床标本培养进行的。 I类抗原通过微淋巴毒性分类。 II类等位基因由聚合酶链反应（PCR）表征。在以下抗原/等位基因中发现了各组之间HLA特异性频率的差异：I组x II组：HLA-A31-p = 0.026; HLA-B41-p = 0.037; HLA-DRB1 * 10-p ＝ 0.037; HLA-DQB1 * 5-p ＝ 0.009。第I组x第III组（对照）：HLA-A31-p = 0.000008;比值比（OR）= 31.75; HLA-B41-p = 0.003; HLA-DQB1 * 5-p ＝ 0.02。在艾滋病和结核病患者中，HLA-A31和HLA-B41抗原以及HLA-DRB1 * 10和HLA-DQB1 * 05等位基因过多（第一组），这表明这些HLA分子与巴西人对结核病的易感性有关艾滋病患者。

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