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首页> 外文期刊>Brazilian Journal of Infectious Diseases >Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
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Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C

机译:可溶性炎性标志物可预测慢性丙型肝炎肝细胞损伤和治疗反应

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Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with chronic hepatitis C.
机译:丙型肝炎是世界范围内的重要负担,是世界各地肝硬化和肝癌的重要原因。宿主免疫应答,尤其是T辅助1型(Th1)细胞介导的宿主免疫应答,似乎在疾病进展中起重要作用,但对于特定治疗后的病毒清除也至关重要。可以使用周围水平的不同细胞因子(例如不同的趋化因子(例如CCL5,CXCL10)和肿瘤坏死因子α(TNF-α))及其可溶性受体(例如可溶性TNF-α受体1(sTNF-R1))来评估免疫激活和2(sTNF-R2)。这篇综述文章集中在潜在的使用外周炎症标记物作为慢性丙型肝炎患者肝组织学变化和治疗反应的预测指标。

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