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首页> 外文期刊>Brazilian Journal of Infectious Diseases >Towards the complete eradication of mother-to-child HIV/HBV coinfection at Saint Camille Medical Centre in Burkina Faso, Africa
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Towards the complete eradication of mother-to-child HIV/HBV coinfection at Saint Camille Medical Centre in Burkina Faso, Africa

机译：在非洲布基纳法索的圣卡米尔医学中心努力彻底根除母婴艾滋病毒/乙肝合并感染

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The coinfection of HIV and hepatitis B virus (HBV) and their vertical transmission constitute a public health problem in sub-Saharan countries of Africa. The objectives of this research are: i) identify the pregnant women that are coinfected by HIV and HBV at Saint Camille Medical Centre; ii) use three antiretroviral drugs (zidovudine, nevirapine and lamivudine) to interrupt the vertical transmission of HIV and HBV from infected mothers; and iii) use the PCR technique to diagnose children who are vertically infected by these viruses in order to offer them an early medical assistance. At Saint Camille Medical Centre, 115 pregnant women, aged from 19 to 41 years, were diagnosed as HIV-positive and, among them, 14 coinfected with HBV. They had at least 32 weeks of amenorrhoea and all of them received the HAART, which contained lamivudine. Two to six months after childbirth, the babies underwent PCR diagnosis for HIV and HBV. The results revealed that, among these mothers, 64.4% were housewives, 36.5% were illiterates, and only 1.7% had a university degree. The rate of vertical transmission of HIV and HBV was 0.0% (0/115) and 21.4% (3/14), respectively. The 3 mothers who transmitted the HBV to their children had all HBsAg, HbeAg, and HBV DNA positive. An antiretroviral therapy that in addition to zidovudine and nevirapine includes lamivudine could, as in the present study, block or reduce the vertical transmission in HIV positive pregnant women who are coinfected with HBV.
机译：在非洲撒哈拉以南国家，艾滋病毒和乙型肝炎病毒（HBV）的共感染及其垂直传播构成了公共卫生问题。这项研究的目的是：i）在圣卡米尔医学中心确定感染了艾滋病毒和乙肝病毒的孕妇; ii）使用三种抗逆转录病毒药物（齐多夫定，奈韦拉平和拉米夫定）打断受感染母亲的HIV和HBV垂直传播; iii）使用PCR技术诊断被这些病毒垂直感染的儿童，以便为他们提供早期医疗帮助。在圣卡米尔医学中心，有115名年龄在19至41岁之间的孕妇被诊断出HIV阳性，其中14例合并感染了HBV。他们至少有32周的闭经，并且所有人都接受了含有拉米夫定的HAART。分娩后两至六个月，对婴儿进行了HIV和HBV的PCR诊断。结果显示，在这些母亲中，家庭主妇占64.4％，文盲占36.5％，大学学历只有1.7％。 HIV和HBV的垂直传播率分别为0.0％（0/115）和21.4％（3/14）。将HBV传染给孩子的3名母亲的HBsAg，HbeAg和HBV DNA均为阳性。如本研究中所述，除齐多夫定和奈韦拉平外，还包括拉米夫定的抗逆转录病毒疗法可以阻断或减少合并感染HBV的HIV阳性孕妇的垂直传播。

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