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首页> 外文期刊>Breast Cancer Research >Molecular biology of breast cancer metastasis Molecular expression of vascular markers by aggressive breast cancer cells
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Molecular biology of breast cancer metastasis Molecular expression of vascular markers by aggressive breast cancer cells

机译：乳腺癌转移的分子生物学侵袭性乳腺癌细胞血管标志物的分子表达

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During embryogenesis, the formation of primary vascular networks occurs via the processes of vasculogenesis and angiogenesis. In uveal melanoma, vasculogenic mimicry describes the 'embryonic-like' ability of aggressive, but not nonaggressive, tumor cells to form networks surrounding spheroids of tumor cells in three-dimensional culture; these recapitulate the patterned networks seen in patients' aggressive tumors and correlates with poor prognosis. The molecular profile of these aggressive tumor cells suggests that they have a deregulated genotype, capable of expressing vascular phenotypes. Similarly, the embryonic-like phenotype expressed by the aggressive human breast cancer cells is associated with their ability to express a variety of vascular markers. These studies may offer new insights for consideration in breast cancer diagnosis and therapeutic intervention strategies.Keywords: breast cancer, interconverted phenotype, thrombin receptor, TIE2
机译：在胚胎发生过程中，主要的血管网络的形成通过血管生成和血管生成过程发生。在葡萄膜黑色素瘤中，血管生成模拟描述了在三维培养中侵袭性但非侵略性肿瘤细胞形成围绕肿瘤细胞球体的网络的“类胚”能力。这些概括了患者侵袭性肿瘤中观察到的模式网络，并与不良预后相关。这些侵袭性肿瘤细胞的分子特征表明它们具有失调的基因型，能够表达血管表型。同样，侵略性人类乳腺癌细胞表达的胚胎样表型与其表达多种血管标记物的能力有关。这些研究可能为乳腺癌的诊断和治疗干预策略提供新的见解。关键词：乳腺癌，相互转化表型，凝血酶受体，TIE2

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