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首页> 外文期刊>Breast Cancer Research >Molecular biology of breast cancer metastasis: Inflammatory breast cancer: clinical syndrome and molecular determinants
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Molecular biology of breast cancer metastasis: Inflammatory breast cancer: clinical syndrome and molecular determinants

机译：乳腺癌转移的分子生物学：炎性乳腺癌：临床综合征和分子决定因素

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Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) that effects approximately 5% of women with breast cancer annually in the USA. It is a clinically and pathologically distinct form of LABC that is particularly fast growing, invasive, and angiogenic. Nearly all women have lymph node involvement at the time of diagnosis, and approximately 36% have gross distant metastases. Despite recent advances in multimodality treatments, the prognosis of patients with IBC is poor, with a median disease-free survival of less than 2.5 years. Recent work on the genetic determinants that underlie the IBC phenotype has led to the identification of genes that are involved in the development and progression of this disease. This work has been aided by the establishment of primary human cell lines and animal models. These advances suggest novel targets for future interventions in the diagnosis and treatment of IBC.Keywords: inflammatory breast cancer, insulin-like growth factor-binding proteins, molecular genetics, RhoC GTPase
机译：炎性乳腺癌（IBC）是一种局部晚期乳腺癌（LABC）的侵略性形式，在美国，每年影响大约5％的乳腺癌女性。它是LABC的临床和病理学独特形式，尤其是快速增长，侵袭性和血管生成性。在诊断时，几乎所有妇女都参与了淋巴结转移，大约36％的妇女发生了远处转移。尽管最近在多模态治疗方面取得了进展，但IBC患者的预后很差，平均无病生存期不到2.5年。关于IBC表型基础的遗传决定因素的最新研究已导致鉴定出与该疾病的发生和发展有关的基因。建立主要的人类细胞系和动物模型有助于这项工作。这些进展为IBC的诊断和治疗提供了新的靶标。关键词：炎症性乳腺癌，胰岛素样生长因子结合蛋白，分子遗传学，RhoC GTPase

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