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首页> 外文期刊>Breast Cancer Research >Age-related terminal duct lobular unit involution in benign tissues from Chinese breast cancer patients with luminal and triple-negative tumors
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Age-related terminal duct lobular unit involution in benign tissues from Chinese breast cancer patients with luminal and triple-negative tumors

机译：患有管腔和三阴性肿瘤的中国乳腺癌患者的年龄相关性终末末梢小叶单位向内退化

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BackgroundTerminal duct lobular unit (TDLU) involution is a physiological process of breast tissue aging characterized by a reduction in the epithelial component. In studies of women with benign breast disease, researchers have found that age-matched women with lower levels of TDLU involution are at increased risk of developing breast cancer. We previously showed that breast cancer cases with core basal phenotype (CBP; estrogen receptor negative [ER?], progesterone receptor-negative [PR?], human epidermal growth factor receptor 2-negative [HER2?], cytokeratins (CK 5 or CK5/6)-positive [CK5/6+] and/or epidermal growth factor receptor-positive [EGFR+]) tumors had significantly reduced TDLU involution compared with cases with luminal A (ER+ and/or PR+, HER2?, CK5/6?, EGFR?) tumors from a population-based case-control study in Poland. We evaluated the association of TDLU involution with tumor subtypes in an independent population of women in China, where the breast cancer incidence rate, prevalence of known risk factors, and mammographic breast density are thought to be markedly different from those of Polish women. MethodsWe performed morphometric assessment of TDLUs by using three reproducible semiquantitative measures that inversely correlate with TDLU involution (TDLU count/100?mm2, TDLU span in micrometer, and acini count/TDLU) by examining benign tissue blocks from 254 age-matched luminal A and 250 triple-negative (TN; ER?, PR?, HER2?, including 125 CBP) breast cancer cases treated in a tertiary hospital in Beijing, China. ResultsOverall, we found that TN and particularly CBP cases tended to have greater TDLU measures (less involution) than luminal A cases in logistic regression models accounting for age, body mass index, parity, and tumor grade. The strongest association was observed for tertiles of acini count among younger women (aged trend 2.11, 95% CI 1.22–3.67, P =?0.008). ConclusionsThese data extend previous findings that TN/CBP breast cancers are associated with reduced TDLU involution in surrounding breast parenchyma compared with luminal A cases among Chinese women, providing further support for differences in the pathogenesis of these tumor subtypes.
机译：背景末端导管小叶单位（TDLU）退化是乳腺组织衰老的生理过程，其特征是上皮成分减少。在对患有乳腺良性疾病的妇女的研究中，研究人员发现，年龄较低的TDLU退化水平较低的女性罹患乳腺癌的风险增加。我们以前曾发现具有核心基础表型（CBP;雌激素受体阴性[ER ？]，孕激素受体阴性[PR ？]，人表皮生长因子受体）的乳腺癌病例2阴性[HER2 ？]，细胞角蛋白（CK 5或CK5 / 6）阳性[CK5 / 6 + ]和/或表皮生长因子受体阳性[EGFR] + ]）肿瘤与管腔A（ER + 和/或PR + ，HER2 ？ ，CK5 / 6 ？，EGFR ？）肿瘤来自波兰一项基于人群的病例对照研究。我们评估了中国女性独立人群中TDLU复性与肿瘤亚型的相关性，据认为乳腺癌发病率，已知危险因素的患病率和乳房X线摄影乳房密度与波兰女性明显不同。方法：我们通过检查良性组织块，使用三种与TDLU对合（TDLU计数/ 100？mm 2 ，TDLU跨度（微米）和腺泡计数/ TDLU）成反比的可再现的半定量测量方法对TDLU进行形态计量学评估。 254例年龄相匹配的管腔A和250例三阴性（TN; ER ？，PR ？，HER2 ？，包括125 CBP）中国北京一家三级医院治疗的癌症病例。结果总体上，我们发现在考虑年龄，体重指数，胎次和肿瘤等级的逻辑回归模型中，TN尤其是CBP病例的TDLU测度（内卷度）比腔A例高。在年轻女性中，痤疮计数的三分位数相关性最强（年龄趋势 2.11，95％CI 1.22–3.67，P =？0.008）。结论这些数据扩展了以前的发现，即与中国女性管腔A病例相比，TN / CBP乳腺癌与周围乳腺实质中的TDLU参与减少有关，为这些肿瘤亚型的发病机理差异提供了进一步的支持。

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