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首页> 外文期刊>Biocontrol Science >Defensive Effects of Human Intestinal Antimicrobial Peptides against Infectious Diseases Caused by Vibrio mimicus and V. vulnificus
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Defensive Effects of Human Intestinal Antimicrobial Peptides against Infectious Diseases Caused by Vibrio mimicus and V. vulnificus

机译：人类肠道抗菌肽对模仿弧菌和 V引起的传染病的防御作用。创伤

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Of human pathogenic Vibrio species, V. mimicus causes gastroenteritis whereas V. vulnificus causes fatal septicemia after consumption of contaminated seafood. These two pathogens produce hemolytic toxins termed V. mimicus hemolysin (VMH) and V. vulnificus hemolysin (VVH), respectively. These toxins elicit the cytolysis of various eukaryotic cells, as well as erythrocytes. The human intestine secretes cationic antimicrobial peptides (AMPs) to prevent infectious diseases. Paneth cells in the small intestine secrete α-defensin 5 (HD-5) and epithelial cells in the large intestine produce LL-37. In the present study, we examined the bactericidal activities of AMPs against V. mimicus and V. vulnificus. Although HD-5 showed no bactericidal activity, LL-37 revealed significant activity against both Vibrio species, suggesting that neither V. mimicus nor V. vulnificus can multiply in the large intestine. We also tested whether AMPs had the ability to inactivate the hemolytic toxins. Only HD-5 was found to inactivate VMH, but not VVH, in a dose-dependent manner through the direct binding to VMH. Therefore, it is considered that V. mimicus cannot penetrate the small intestinal epithelium because the cytolytic action of VMH is inactivated by HD-5.
机译：关于人类致病性弧菌， V。拟态引起肠胃炎，而V。食用受污染的海鲜后，创伤会导致致命的败血病。这两种病原体产生称为V的溶血毒素。模仿溶血素（VMH）和V。创伤性溶血素（VVH）。这些毒素引起各种真核细胞以及红细胞的细胞溶解。人肠分泌阳离子抗菌肽（AMPs）来预防传染病。小肠中的Paneth细胞分泌α-防御素5（HD-5），大肠中的上皮细胞分泌LL-37。在本研究中，我们检查了AMPs对V的杀菌活性。拟态和 V。创伤尽管HD-5没有显示杀菌活性，但是LL-37显示出针对两种弧菌的显着活性，表明两者均没有。模仿物或 V。创伤可以在大肠中繁殖。我们还测试了AMPs是否具有灭活溶血毒素的能力。通过直接结合至VMH，仅HD-5被发现以剂量依赖的方式使VMH失活，但未使VVH失活。因此，认为是V。模拟物不能穿透小肠上皮，因为HD-5使VMH的细胞溶解作用失活。

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