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In vitro Anti-Influenza Virus Activity of Agaricus brasiliensis KA21.

机译：巴西姬松茸KA21的体外抗流感病毒活性。

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摘要

Agaricus is known to have immunostimulatory and anti-tumor effects. However, the antiviral effects of Agaricus have not yet been examined. In the present study, the antiviral effects of an extract of Agaricus brasiliensis KA21 (AE) on the H1N1 influenza virus (PR8 strain) were investigated.　The anti-influenza virus effects of AE were examined by using the plaque formation inhibition test. AE inhibited the plaque formation of PR8 in a dose-dependent manner: 98 and 50% (IC50) inhibition at 2.5 and 0.99 mg/mL, respectively. To elucidate the mechanisms of AE, the direct actions and adsorption and invasion inhibition of AE were examined, and were found to have no inhibitory effect on PR8 infection. Thus, in vitro antiviral effects may somehow inhibit PR8 after the viral invasion of cells. These results demonstrated that it is expected that AE can effectively prevent the spread of the influenza virus.
机译：已知姬松茸具有免疫刺激和抗肿瘤作用。但是，尚未研究姬松茸的抗病毒作用。在本研究中，研究了巴西姬松茸KA21（AE）提取物对H1N1流感病毒（PR8株）的抗病毒作用。通过噬斑形成抑制试验检查了AE的抗流感病毒作用。 AE以剂量依赖性方式抑制PR8的斑块形成：分别以2.5和0.99 mg / mL抑制98％和50％（IC50）。为了阐明AE的机理，研究了AE的直接作用以及吸附和侵袭抑制，发现它们对PR8感染没有抑制作用。因此，体外抗病毒作用可能以某种方式抑制病毒侵入细胞后的PR8。这些结果表明，期望AE可以有效地防止流感病毒的传播。

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