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In vitro Anti-Influenza Virus Activity of Agaricus brasiliensis KA21

机译：姬松茸的体外抗流感病毒活性Ka21

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Agaricus is known to have immunostimulatory and anti-tumor effects. However, the antiviral effects of Agaricus have not yet been examined. In the present study, the antiviral effects of an extract of Agaricus brasiliensis KA21 (AE) on the H1N1 influenza virus (PR8 strain) were investigated.The anti-influenza virus effects of AE were examined by using the plaque formation inhibition test. AE inhibited the plaque formation of PR8 in a dose-dependent manner: 98 and 50% (IC50) inhibition at 2.5 and 0.99 mg/mL, respectively. To elucidate the mechanisms of AE, the direct actions and adsorption and invasion inhibition of AE were examined, and were found to have no inhibitory effect on PR8 infection. Thus, in vitro antiviral effects may somehow inhibit PR8 after the viral invasion of cells. These results demonstrated that it is expected that AE can effectively prevent the spread of the influenza virus.
机译：已知姬松茸具有免疫刺激和抗肿瘤作用。 然而，尚未检查炎症的抗病毒作用。 在本研究中，研究了Agaricus Brasiliensis Ka21（AE）提取物对H1N1流感病毒（PR8菌株）的抗病毒作用。通过使用斑块形成抑制试验检查AE的抗流感病毒作用。 AE以剂量依赖性方式抑制PR8的斑块形成：98和50％（IC 50）分别在2.5和0.99mg / mL处抑制。 为了阐明AE的机制，检查了AE的直接作用和吸附和侵袭抑制，并发现对PR8感染没有抑制作用。 因此，体外抗病毒效果可能在病毒侵袭细胞的病毒侵袭后以某种方式抑制PR8。 这些结果表明，预期AE可以有效地防止流感病毒的扩散。

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