• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Breast Cancer: Basic and Clinical Research >Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis
【24h】

Altered Endoplasmic Reticulum Calcium Pump Expression during Breast Tumorigenesis

机译：乳腺肿瘤发生过程中内质网钙泵表达的改变

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Endoplasmic reticulum calcium homeostasis is involved in several essential cell functions including cell proliferation, protein synthesis, stress responses or secretion. Calcium uptake into the endoplasmic reticulum is performed by Sarco/Endoplasmic Reticulum Calcium ATPases (SERCA enzymes). In order to study endoplasmic reticulum calcium homeostasis in situ in mammary tissue, in this work SERCA3 expression was investigated in normal breast and in its benign and malignant lesions in function of the cell type, degree of malignancy, and histological and molecular parameters of the tumors. Our data indicate, that although normal breast acinar epithelial cells express SERCA3 abundantly, its expression is strongly decreased already in very early non-malignant epithelial lesions such as adenosis, and remains low in lobular carcinomas. Whereas normal duct epithelium expresses significant amounts of SERCA3, its expression is decreased in several benign ductal lesions, as well as in ductal adenocarcinoma. The loss of SERCA3 expression is correlated with Elston-Ellis grade, negative hormone receptor expression or triple negative status in ductal carcinomas. The concordance between decreased SERCA3 expression and several histological, as well as molecular markers of ductal carcinogenesis indicates that endoplasmic reticulum calcium homeostasis is remodeled during tumorigenesis in the breast epithelium.
机译：内质网钙稳态涉及多种基本细胞功能，包括细胞增殖，蛋白质合成，应激反应或分泌。钙吸收到内质网是由Sarco /内质网钙ATP酶（SERCA酶）完成的。为了研究乳腺组织内质网钙稳态，在这项工作中，研究了SERCA3在正常乳腺及其良性和恶性病变中的表达，涉及细胞类型，恶性程度以及肿瘤的组织学和分子参数。我们的数据表明，尽管正常的乳房腺泡上皮细胞大量表达SERCA3，但在非常早期的非恶性上皮病变（如腺病）中，其表达已大大降低，而在小叶癌中仍然很低。正常导管上皮表达大量SERCA3，而在一些良性导管病变以及导管腺癌中其表达降低。导管癌中SERCA3表达的丧失与Elston-Ellis分级，激素受体阴性或三阴性状态相关。降低的SERCA3表达与几种组织学以及导管癌变的分子标记之间的一致性表明，在乳腺上皮发生肿瘤的过程中，内质网钙稳态得以重塑。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号