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首页> 外文期刊>British Biotechnology Journal >Genomic Analysis of Fungal Species No.11243Mutant Strains Provides Insights into theRelationship between Mutations andHigh Productivity
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Genomic Analysis of Fungal Species No.11243Mutant Strains Provides Insights into theRelationship between Mutations andHigh Productivity

机译：真菌物种11243突变菌株的基因组分析为突变与高生产力之间的关系提供了见解

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Aims: FR901469 is a novel antifungal antibiotic produced by fungal species No.11243. Although we have several FR901469 high-producing mutant strains, the mechanism of high productivity is unclear. This study aims to unravel the relationship between mutations and FR901469 productivity.Methodology: We performed genome sequence analysis of mutant strains and detected mutated genes. Subsequently, we classified mutated genes into functional categories and searched the categories in which mutated genes were accumulated as generations progressed.Results: We found that genome regions of two scaffolds were amplified and one of those contained putative FR901469 biosynthesis gene cluster. Moreover, we detected totally 396 mutated genes from 14 mutant strains and the genes within the “Replication, recombination and repair”, “Signal transduction mechanisms” and “Transcription” categories accumulated this mutation.Conclusion: Our study suggests that productivity improvement occurs via the following two mechanisms: the amplification of putative FR901469 biosynthesis gene cluster and mutations of genes categorized as “Replication, recombination and repair”, “Signal transduction mechanisms” and “Transcription”.
机译：目的：FR901469是一种新型真菌，由11243号真菌种产生。尽管我们有几个FR901469高产突变菌株，但高生产率的机制尚不清楚。本研究旨在揭示突变与FR901469生产率之间的关系。方法：我们对突变菌株进行了基因组序列分析，并检测了突变的基因。结果，我们发现两个支架的基因组区域被扩增，其中一个包含推测的FR901469生物合成基因簇。此外，我们检测到来自14个突变菌株的396个突变基因，并且“复制，重组和修复”，“信号转导机制”和“转录”类别中的基因积累了该突变。以下两个机制：假定的FR901469生物合成基因簇的扩增以及归类为“复制，重组和修复”，“信号转导机制”和“转录”的基因突变。

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