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首页> 外文期刊>British Biotechnology Journal >Influence of Dominant Follicle and Corpusluteum on Recovery of Good Quality Oocytesfor In vitro Embryo Production in Cattle
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Influence of Dominant Follicle and Corpusluteum on Recovery of Good Quality Oocytesfor In vitro Embryo Production in Cattle

机译：优势卵泡和小体对牛体外培养生产优质卵母细胞的影响

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The quality of oocytes is more critical for the success of bovine in vitro embryo production (IVP) than the conditions of in vitro culture of these structures. Despite knowledge about bovine follicular development, especially gonadotropin-dependent phase, be considerably wide, knowledge about effects of the estrous cycle phase, follicular or luteal, on recovery of oocytes may strongly contribute to improve IVP efficiency. Previous efforts to find the proper cumulus-oocyte complex (COC) in vitro maturation conditions did not improve this technique at level of the in vivo embryo production. In physiological conditions the oocyte to be fertilized is donated by healthy follicles during a specific stage of the estrous cycle. However, COCs collected for IVP are obtained from follicles disregarding the follicular phase; consequently, they may have been subjected to different levels of estradiol, progesterone, FSH and LH. Plasma progesterone affects oocyte quality probably because it allows the follicle is exposed for a long period to low amplitude LH pulses, resulting in good quality oocyte. Besides, the presence of a functional corpus luteum (CL) in the ovary may interfere with the amount and quality of oocytes, CL is related to a high vascularization of the ovary which can propitiate an optimal hormonal and nutritional environment for developing follicles. Moreover, the developmental ability of oocytes from small follicles can be influenced by a presence of dominant follicle. Therefore, the ovarian condition of regularly cyclic females needs to be a concern in collection of oocytes for commercial IVP.
机译：卵母细胞的质量对于牛体外胚胎生产（IVP）的成功比这些结构的体外培养条件更为关键。尽管有关牛卵泡发育，尤其是促性腺激素依赖性相的知识相当广泛，但有关发情周期相（卵泡或黄体）对卵母细胞恢复的影响的知识可能会极大地有助于提高IVP效率。先前在体外成熟条件下寻找合适的卵-卵母细胞复合体（COC）的努力并未在体内胚胎产生水平上改善该技术。在生理条件下，在动情周期的特定阶段，健康卵泡捐赠了要受精的卵母细胞。但是，为IVP收集的COC是从不考虑卵泡期的卵泡中获得的。因此，它们可能已经历了不同水平的雌二醇，孕酮，FSH和LH。血浆孕酮会影响卵母细胞的质量，可能是因为它使卵泡长时间暴露于低振幅的LH脉冲，从而产生高质量的卵母细胞。此外，卵巢中功能性黄体（CL）的存在可能会干扰卵母细胞的数量和质量。CL与卵巢的高血管形成有关，可以促进卵泡发育的最佳激素和营养环境。此外，优势卵泡的存在会影响小卵泡卵母细胞的发育能力。因此，在商业IVP的卵母细胞收集中，有规律的周期性雌性的卵巢状况需要引起关注。

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