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首页> 外文期刊>British Biotechnology Journal >Relation of Sirtuin 1 Gene Polymorphisms withLipid Profile in Hemodialysis Patients
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Relation of Sirtuin 1 Gene Polymorphisms withLipid Profile in Hemodialysis Patients

机译：血液透析患者Sirtuin 1基因多态性与脂质谱的关系

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Very little is known about the genetic variation of SIRT 1 and its effects on energy homeostasis in humans. Mammalian SIRT1deacetylates a host of target proteins that are important for apoptosis, the cell cycle, circadian rhythms, mitochondrial function and metabolism. In particular, much current research focuses on the impact of SIRT1 in glucose homeostasis, lipid metabolism and energy balance. Objective: To study the relationship of sirtuin 1 gene polymorphisms with lipids profile in hemodialysis patients. Subjects and Methods: This study included 70 Egyptian subjects (45 patients on hemodialysis and 25 age and gender matched healthy control group). The genotyping of SIRT1 rs7895833 in the promoter region, rs7069102 in intron 4, and rs2273773 in exon 5 was performed using polymerase chain reaction with confronting two-pair primers assay (CTPP). Serum TC, TG, HDLc, LDLc, fasting glucose, urea and creatinine were measured by standard colorimetric methods. Results: The patients had higher diastolic and systolic BP (P0.001), fasting blood glucose (P0.001), TC (P0.001), TG (P=0.006), LDLc (P=0.004), urea (P0.001) and creatinine (P0.001). Males and female patients differ according to cause of hemodialysis (P= 0.02) and serum creatinine (P=0.007). Control subjects of sirtuin1 rs7895833 showed significant A allele compared with patients (46% vs. 27.78% P= 0.04) while C allele of sirtuin1 rs7069102 not differ between groups (P0.05). Sirtuin 1 rs2273773, patients showed significant lower frequency of C allele compared with control (26.67% vs.44% P= 0.04,). Conclusion: Significant association of SIRT1 rs7895833 and rs2273773 polymorphisms with dyslipidemia and blood pressure may modulate disease course in hemodialysis.
机译：关于SIRT 1的遗传变异及其对人类能量稳态的影响知之甚少。哺乳动物SIRT1使许多靶蛋白脱乙酰化，这些靶蛋白对于细胞凋亡，细胞周期，昼夜节律，线粒体功能和代谢都很重要。特别是，当前许多研究集中在SIRT1对葡萄糖稳态，脂质代谢和能量平衡的影响上。目的：探讨血液透析患者中​​sirtuin 1基因多态性与血脂谱的关系。受试者和方法：这项研究包括70名埃及受试者（45名接受血液透析的患者和25名年龄和性别相匹配的健康对照组）。 SIRT1 rs7895833在启动子区域，内含子4在rs7069102和外显子5在rs2273773的基因分型是通过聚合酶链反应和两对引物对（CTPP）进行的。血清TC，TG，HDLc，LDLc，空腹血糖，尿素和肌酐通过标准比色法测量。结果：患者的舒张压和收缩压较高（P <0.001），空腹血糖（P <0.001），TC（P <0.001），TG（P = 0.006），LDLc（P = 0.004），尿素（P < 0.001）和肌酐（P <0.001）。男性和女性患者根据血液透析原因（P = 0.02）和血清肌酐（P = 0.007）而有所不同。 sirtuin1 rs7895833的对照受试者与患者相比显示出显着的A等位基因（46％比27.78％P = 0.04），而sirtuin1 rs7069102的C等位基因在各组之间无差异（P> 0.05）。 Sirtuin 1 rs2273773，与对照组相比，患者的C等位基因频率显着降低（26.67％vs. 44％P = 0.04）。结论：SIRT1 rs7895833和rs2273773多态性与血脂异常和血压的显着相关可能调节血液透析的病程。

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