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首页> 外文期刊>Biocontrol Science >Bactericidal Effects and Cytotoxicity of New Aromatic Dialdehyde Disinfectants (Ortho-phthalaldehyde)
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Bactericidal Effects and Cytotoxicity of New Aromatic Dialdehyde Disinfectants (Ortho-phthalaldehyde)

机译：新型芳香二醛消毒剂（邻苯二甲醛）的杀菌作用和细胞毒性

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??We investigated the bactericidal effects and cytotoxicity of an ortho-phthalaldehyde product in comparison with those of its predecessor glutaraldehyde products. Bactericidal effects ware examined on Mycobacterium terrae , a standard organism used for investigating the bactericidal effect of high-level disinfectants. Cytotoxicity as determined by the MTT assay was examined by using four cell lines. The colony forming test, a method to examine residual toxicity, and the evaporation test, a newly developed method to examine the toxicity of the evaporated ingredients, were performed. Test solutions were 2.25% and 3.5% glutaraldehyde (GA) products and a 0.55% ortho-phthalaldehyde (OPA) product, and glutaraldehyde itself. All the disinfectants showed sufficient bactericidal effects on M. terrae . Meanwhile, the OPA product was less toxic than GA products and GA itself to all the cell lines tested. The colony forming test showed that GA products and GA itself exerted residual cytotoxicity more potently than did the OPA product. The evaporation test showed that GA products and GA itself exerted cytotoxicity via evaporation more potently than did the OPA product. In conclusion, OPA appears to be less cytotoxic than GA even though bactericidal effects were comparable. This may be due to the lower concentration of the active ingredient (ortho-phthalaldehyde) in the OPA product .
机译：我们研究了邻苯二甲醛产品与其前身戊二醛产品相比的杀菌效果和细胞毒性。在土壤分枝杆菌（一种用于研究高级消毒剂的杀菌作用的标准生物）上检测了杀菌效果。通过使用四种细胞系检查通过MTT测定法测定的细胞毒性。进行了菌落形成试验（一种检查残留毒性的方法）和蒸发试验（一种新开发的用于检查蒸发成分的毒性的方法）。测试溶液为2.25％和3.5％的戊二醛（GA）产品和0.55％的邻苯二甲醛（OPA）产品以及戊二醛本身。所有消毒剂均对M具有足够的杀菌作用。地。同时，OPA产品的毒性要比GA产品和GA本身对所有测试的细胞系低。菌落形成试验表明，GA产品和GA本身比OPA产品更有效地发挥残余细胞毒性作用。蒸发测试表明，GA产物和GA本身比OPA产物更有效地通过蒸发发挥了细胞毒性作用。总之，尽管杀菌效果相当，但OPA的细胞毒性似乎不如GA。这可能是由于OPA产品中活性成分（邻苯二甲醛）的浓度较低。

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