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首页> 外文期刊>BMC Microbiology >Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice
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Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice

机译：一些假定的益生元会增加小鼠沙门氏菌血清鼠伤寒感染的严重程度

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Background Prebiotics are non-digestible food ingredients believed to beneficially affect host health by selectively stimulating the growth of the beneficial bacteria residing in the gut. Such beneficial bacteria have been reported to protect against pathogenic infections. However, contradicting results on prevention of Salmonella infections with prebiotics have been published. The aim of the present study was to examine whether S. Typhimurium SL1344 infection in mice could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles. BALB/c mice were fed a diet containing 10% of either of the following carbohydrates: inulin, fructo-oligosaccharide, xylo-oligosaccharide, galacto-oligosaccharide, apple pectin, polydextrose or beta-glucan for three weeks prior to oral Salmonella challenge (107 CFU) and compared to mice fed a cornstarch-based control diet. Results The mice fed with diets containing fructo-oligosaccharide (FOS) or xylo-oligosaccharide (XOS) had significantly higher (P S. Typhimurium SL1344 in liver, spleen and mesenteric lymph nodes when compared to the mice fed with the cornstarch-based control diet. Significantly increased amounts (P Salmonella were detected in ileal and fecal contents of mice fed with diets supplemented with apple pectin, however these mice did not show significantly higher numbers of S. Typhimyrium in liver, spleen and lymph nodes than animals from the control group (P The acute-phase protein haptoglobin was a good marker for translocation of S. Typhimurium in mice. In accordance with the increased counts of Salmonella in the organs, serum concentrations of haptoglobin were significantly increased in the mice fed with FOS or XOS (P In vitro fermentation in monocultures revealed that S. Typhimurium SL1344 is capable of fermenting FOS, beta-glucan and GOS with a corresponding decline in pH. Conclusion Supplementing a cornstarch-based rodent diet with 10% FOS or XOS was found to increase the translocation of S. Typhimurium SL1344 to internal organs in mice, while 10% apple pectin was found to increase the numbers of S. Typhimurium in intestinal content and feces.
机译：背景技术益生元是不可消化的食品成分，据信可以通过选择性刺激肠道中有益细菌的生长来有益地影响宿主健康。据报道，这种有益细菌可以防止病原体感染。但是，有关预防益生元沙门氏菌感染的结果却相互矛盾。本研究的目的是研究是否可以通过给予具有不同结构和消化率特征的饮食碳水化合物来预防鼠伤寒沙门氏菌SL1344感染。在口服沙门氏菌攻击前三周，给BALB / c小鼠喂食含10％以下碳水化合物之一的饮食：菊粉，低聚果糖，低聚木糖，低聚半乳糖，苹果果胶，聚葡萄糖或β-葡聚糖（10 7 CFU），并与饲喂基于玉米淀粉的对照饮食的小鼠进行比较。结果饲喂含果糖低聚糖（FOS）或木糖低聚糖（XOS）的饮食的小鼠与饲喂以玉米淀粉为基础的对照饮食的小鼠相比，肝脏，脾脏和肠系膜淋巴结中的鼠伤寒杆菌SL1344明显更高。显着增加的数量（在补充苹果果胶饮食的小鼠中，回肠和粪便中检出了沙门氏菌，但是这些小鼠的肝脏，脾脏和淋巴结中的鼠伤寒沙门氏菌数量没有明显高于对照组。 （P急性期蛋白触珠蛋白是鼠伤寒沙门氏菌易位的良好标志物。随着器官中沙门氏菌计数的增加，用FOS或XOS喂养的小鼠血清触珠蛋白浓度显着增加（P在单培养物中的体外发酵表明，鼠伤寒沙门氏菌SL1344能够发酵FOS，β-葡聚糖和GOS，且pH值相应降低。发现用10％FOS或XOS补充玉米淀粉基啮齿动物饮食会增加鼠伤寒沙门氏菌SL1344向小鼠内脏器官的转运，而发现10％苹果果胶会增加鼠伤寒沙门氏菌在肠内和粪便中的数量。 。

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