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首页> 外文期刊>BMC Musculoskeletal Disorders >Is there a role for Digital X-ray Radiogrammetry as surrogate marker for radiological progression and imaging of structural integrity in rheumatoid arthritis?
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Is there a role for Digital X-ray Radiogrammetry as surrogate marker for radiological progression and imaging of structural integrity in rheumatoid arthritis?

机译：数字X射线放射线照相术是否可作为类风湿关节炎的放射学进展和结构完整性成像的替代标志物？

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Introduction The established scoring techniques based on radiographs present limitations in the evaluation of structural integrity due to high effectiveness of innovative therapeutic strategies. The aim of this study was to evaluate the periarticular mineralisation as detected by Digital X-ray Radiogrammetry (DXR) as surrogate marker for structural integrity during the course of rheumatoid arthritis (RA). Methods 11 centers throughout Germany contributed data of 94 patients with verified RA. The patients were treated with leflunomide or methotrexate during a mean observation period of 22?months. All patients underwent complete computerized calculations of bone mineral density (BMD) and metacarpal index (MCI) by DXR using digitized hand radiographs. The radiological assessment of disease progression was estimated by the Sharp Score. Results The Sharp Score revealed no significant change during the study period. DXR-BMD revealed minimal decrease of ?1.4?% (leflunomide group) versus a higher reduction of ?4.3?% (methotrexate group). Regarding DXR-MCI, a reduction of ?2.2?% (leflunomide group) and ?4.9?% (methotrexate group) was observed. Conclusion Quantitative data of hand bone mass estimated by the presented DXR-technique may be a complementary precise tool in the identification of RA-related radiographic changes and in the assessment of structural integrity.
机译：引言由于创新性治疗策略的高度有效性，基于放射线照片的既定评分技术在评估结构完整性方面存在局限性。这项研究的目的是评估通过数字X射线放射线照相术（DXR）检测的关节周围矿化，作为类风湿关节炎（RA）过程中结构完整性的替代标志。方法德国的11个中心贡献了94例经验证的RA患者的数据。患者在平均观察期22个月内接受来氟米特或甲氨蝶呤治疗。所有患者均通过数字化X射线手腕摄影术通过DXR对骨密度（BMD）和掌骨指数（MCI）进行了完全计算机化的计算。疾病进展的放射学评估由夏普评分（Sharp Score）估算。结果在研究期间，夏普分数显示无明显变化。 DXR-BMD显示最小降低幅度为1.4％（来氟米特组），而最大降低幅度为4.3％（甲氨蝶呤组）。关于DXR-MCI，观察到减少了2.2％（来氟米特组）和4.9％（甲氨蝶呤组）。结论所提出的DXR技术估算的手骨质量定量数据可能是鉴定RA相关放射线变化和评估结构完整性的补充精确工具。

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