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首页> 外文期刊>BMC Neuroscience >Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patients
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Evidence for cognitive vestibular integration impairment in idiopathic scoliosis patients

机译：特发性脊柱侧弯患者认知前庭整合障碍的证据

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Background Adolescent idiopathic scoliosis is characterized by a three-dimensional deviation of the vertebral column and its etiopathogenesis is unknown. Various factors cause idiopathic scoliosis, and among these a prominent role has been attributed to the vestibular system. While the deficits in sensorimotor transformations have been documented in idiopathic scoliosis patients, little attention has been devoted to their capacity to integrate vestibular information for cognitive processing for space perception. Seated idiopathic scoliosis patients and control subjects experienced rotations of different directions and amplitudes in the dark and produced saccades that would reproduce their perceived spatial characteristics of the rotations (vestibular condition). We also controlled for possible alteration of the oculomotor and vestibular systems by measuring the subject's accuracy in producing saccades towards memorized peripheral targets in absence of body rotation and the gain of their vestibulo-ocular reflex. Results Compared to healthy controls, the idiopathic scoliosis patients underestimated the amplitude of their rotations. Moreover, the results revealed that idiopathic scoliosis patients produced accurate saccades to memorized peripheral targets in absence of body rotation and that their vestibulo-ocular reflex gain did not differ from that of control participants. Conclusion Overall, results of the present study demonstrate that idiopathic scoliosis patients have an alteration in cognitive integration of vestibular signals. It is possible that severe spine deformity developed partly due to impaired vestibular information travelling from the cerebellum to the vestibular cortical network or alteration in the cortical mechanisms processing the vestibular signals.
机译：背景技术青少年特发性脊柱侧凸的特征是椎骨的三维偏移，其发病机理尚不清楚。各种因素引起特发性脊柱侧弯，其中，前庭系统起着重要作用。虽然在特发性脊柱侧凸患者中已记录到感觉运动转换的缺陷，但很少有人关注他们整合前庭信息以进行空间感知认知处理的能力。坐着的特发性脊柱侧弯患者和对照对象在黑暗中经历了不同方向和幅度的旋转，并产生了扫视，这些扫视将再现他们感知到的旋转的空间特征（前庭状态）。我们还通过测量对象在没有身体旋转的情况下朝着记忆的周围目标产生扫视的准确性以及获得前庭眼反射的能力来控制动眼和前庭系统的可能改变。结果与健康对照组相比，特发性脊柱侧弯患者低估了其旋转幅度。此外，结果显示，特发性脊柱侧弯患者在没有身体旋转的情况下可以精确地扫视记忆的周围目标，其前庭眼反射增益与对照组无差异。结论总的来说，本研究的结果表明，特发性脊柱侧凸患者的前庭信号认知整合发生了改变。严重的脊柱畸形可能部分是由于受损的前庭信息从小脑传播到前庭皮质网络或处理前庭信号的皮质机制发生了改变。

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