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首页> 外文期刊>BMC Neuroscience >Transient filament occlusion of the middle cerebral artery in rats: does the reperfusion method matter 24 hours after perfusion?
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Transient filament occlusion of the middle cerebral artery in rats: does the reperfusion method matter 24 hours after perfusion?

机译：大鼠大脑中动脉的瞬时细丝闭塞：灌注后24小时再灌注方法重要吗？

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Background There are two widely used transient middle cerebral artery occlusion (MCAO) methods, which differ in the use of unilateral or bilateral carotid artery reperfusion (UNICAR and BICAR). Of the two methods, UNICAR is easier to perform. This study was designed to comprehensively compare the two reperfusion methods to determine if there are any differences in outcomes. Results The UNICAR and BICAR groups each included 9 rats . At baseline, the average pO2 was 20.54?±?9.35 and 26.43?±?7.39, for the UNICAR and BICAR groups, respectively ( P =?0.519). Changes in pO2, as well as other physiological parameters measured within the ischemic lesion, were similar between the UNICAR and BICAR groups during 90 min of MCAO and the first 30 min of reperfusion (all P >?0.05). Furthermore, both the Bederson score and Garcia score, which are used for neurological assessment, were also similar (both P >?0.05). There were also no significant differences in T2WI lesion volume, DWI lesion volume, PWI lesion volume, or TTC staining infarct volume between the two groups (all P >?0.05). Conclusion UNICAR and BICAR have similar capability for inducing acute brain ischemic injury and can be considered interchangeable up to 24 hours after reperfusion.
机译：背景技术有两种广泛使用的短暂性大脑中动脉闭塞（MCAO）方法，它们在单侧或双侧颈动脉再灌注（UNICAR和BICAR）的使用上有所不同。在这两种方法中，UNICAR更易于执行。本研究旨在全面比较两种再灌注方法，以确定结果是否存在差异。结果UNICAR组和BICAR组各包括9只大鼠。基线时，UNICAR和BICAR组的平均pO 2 分别为20.54±9.35和26.43±7.39（P = 0.519）。在MCAO的90分钟和再灌注的前30分钟，UNICAR组和BICAR组之间在缺血性病变中测量的pO 2 以及其他生理参数的变化相似（所有P>？0.05 ）。此外，用于神经系统评估的Bederson评分和Garcia评分也相似（均P>？0.05）。两组之间的T2WI病变体积，DWI病变体积，PWI病变体积或TTC染色梗死体积也没有显着差异（所有P>？0.05）。结论UNICAR和BICAR具有相似的诱导急性脑缺血性损伤的能力，并且在再灌注后24小时内可以互换。

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