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首页> 外文期刊>BMC Nephrology >Seroprevalence of Streptococcal Inhibitor of Complement (SIC) suggests association of streptococcal infection with chronic kidney disease
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Seroprevalence of Streptococcal Inhibitor of Complement (SIC) suggests association of streptococcal infection with chronic kidney disease

机译：链球菌补体抑制剂的血清阳性率提示链球菌感染与慢性肾脏疾病相关

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Background Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion of subjects with past history of PSGN than without the history exhibited seroreactions to streptococcal antigens called streptococcal inhibitor of complement (SIC) and to distantly related SIC (DRS). These antigens are expressed by major PSGN-associated GAS types. We therefore predicted that in populations such as India, which is endemic for streptococcal diseases and which has high prevalence of CKD and ESRD, greater proportions of CKD and ESRD patients exhibit seroreaction to SIC and DRS than healthy controls. Methods To test this we conducted a SIC and DRS seroprevalence study in subjects from Mumbai area. We recruited 100 CKD, 70 ESRD and 70 healthy individuals. Results Nineteen and 35.7% of CKD and ESRD subjects respectively were SIC antibody-positive, whereas only 7% of healthy cohort was seropositive to SIC. Furthermore, significantly greater proportion of the ESRD patients than the CKD patients is seropositive to SIC (p=0.02; odds ratio 2.37). No association was found between the renal diseases and DRS-antibody-positivity. Conclusions Past infection with SIC-positive GAS is a risk factor for CKD and ESRD in Mumbai population. Furthermore, SIC seropositivity is predictive of poor prognosis of CKD patients.
机译：背景技术A组链球菌（GAS）是链球菌性肾小球肾炎（PSGN）后免疫介导的后遗症的病原体。在某些人群中，PSGN被认为是慢性肾脏疾病（CKD）和终末期肾脏疾病（ESRD）的危险因素。发现具有PSGN既往史的受试者中，与没有史的受试者相比，对被称为补体链球菌抑制剂（SIC）的链球菌抗原和与远缘相关的SIC（DRS）的血清反应显着增加。这些抗原由与PSGN相关的主要GAS类型表达。因此，我们预测，在印度这样的人群中，该人群是链球菌疾病的地方病，并且CKD和ESRD的患病率较高，与健康对照组相比，CKD和ESRD患者对SIC和DRS表现出血清反应。方法为了测试这一点，我们在孟买地区的受试者中进行了SIC和DRS血清阳性率研究。我们招募了100名CKD，70名ESRD和70名健康个体。结果CKD和ESRD受试者分别有19例和35.7％为SIC抗体阳性，而健康人群中仅有7％为SIC血清阳性。此外，与CKD患者相比，ESRD患者中血清SIC呈阳性（p = 0.02;优势比2.37）。肾脏疾病与DRS抗体阳性之间未发现关联。结论过去SIC阳性GAS感染是孟买人群CKD和ESRD的危险因素。此外，SIC血清反应阳性可预测CKD患者的预后不良。

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