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首页> 外文期刊>BMC Pediatrics >Manipulation of drugs to achieve the required dose is intrinsic to paediatric practice but is not supported by guidelines or evidence
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Manipulation of drugs to achieve the required dose is intrinsic to paediatric practice but is not supported by guidelines or evidence

机译：达到所需剂量的药物操纵是儿科实践所固有的，但没有指导原则或证据支持

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Background A lack of age-appropriate formulations can make it difficult to administer medicines to children. A manipulation of the dosage form may be required to achieve the required dose. This study aimed to describe medicines that are manipulated to achieve the required dose in paediatric practice. Method A structured, undisguised observational study and postal survey. The observational study investigated drug manipulations occurring in clinical practice across three sites. The questionnaire, administered to a sample of paediatric nurses throughout the UK, surveyed manipulations conducted and nurses’ experiences and views. Results The observational study identified 310 manipulations, of which 62% involved tablets, 21% were intravenous drugs and 10% were sachets. Of the 54 observed manipulations 40 involved tablets with 65% of the tablets being cut and 30% dispersed to obtain a smaller dose. 188 manipulations were reported by questionnaire respondents, of these 46% involved tablets, 12% were intravenous drugs, and 12% were nebuliser solutions. Manipulations were predominantly, but not exclusively, identified in specialist clinical areas with more highly dependent patients. Questionnaire respondents were concerned about the accuracy of the dose achieved following manipulations and the lack of practice guidance. Conclusion Manipulations to achieve the required dose occur throughout paediatric in-patient settings. The impact of manipulations on the efficacy of the drugs, the accuracy of the dose and any adverse effects on patients is not known. There is a need to develop evidence-based guidance for manipulations of medicines in children.
机译：背景技术缺乏适合年龄的制剂可能使向儿童服用药物变得困难。可能需要操纵剂型以达到所需剂量。这项研究旨在描述在儿科实践中被操纵以达到所需剂量的药物。方法一种结构化，不变的观察性研究和邮政调查。观察性研究调查了在三个地方的临床实践中发生的药物操纵情况。该调查问卷是针对全英国的儿科护士样本进行的，调查了进行的操作以及护士的经验和观点。结果观察性研究确定了310种操作方式，其中62％涉及片剂，21％为静脉药物和10％为香囊。在观察到的54种操作中，有40种涉及药片，其中有65％的药片被切开，而30％的药片分散以获得较小的剂量。问卷受访者报告了188次操作，其中46％的片剂，12％的静脉注射药物和12％的雾化溶液。在具有较高依赖性的患者的专业临床领域中，主要但并非唯一地确定了操作。问卷受访者担心操作后达到的剂量准确性以及缺乏实践指导。结论在整个儿科住院患者中均会进行操作以达到所需剂量。操作对药物功效，剂量准确性以及对患者的不良影响的影响尚不清楚。有必要为操纵儿童药物制定循证指南。

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