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首页> 外文期刊>BMC Pediatrics >Growth of HIV-exposed uninfected, compared with HIV-unexposed, Zambian children: a longitudinal analysis from infancy to school age
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Growth of HIV-exposed uninfected, compared with HIV-unexposed, Zambian children: a longitudinal analysis from infancy to school age

机译：与未接触艾滋病毒的赞比亚儿童相比，未接触艾滋病毒的儿童的增长：从婴儿期到学龄的纵向分析

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Background Early growth of HIV-exposed, uninfected (HEU) children is poorer than that of their HIV-unexposed, uninfected (HUU) counterparts but there is little longitudinal or longer term information about the growth effects of early HIV exposure. Methods We performed a longitudinal analysis to compare growth of HEU and HUU infants and children using data from two cohort studies in Lusaka, Zambia. Initially 207 HUU and 200 HEU infants from the Breastfeeding and Postpartum Health (BFPH) study and 580 HUU and 165 HEU from the Chilenje Infant Growth, Nutrition and Infection Study (CIGNIS) had anthropometric measurements taken during infancy and again when school-aged, at which time 66 BFPH children and 326 CIGNIS children were available. We analysed the data from the two cohorts separately using linear mixed models. Linear regression models were used as a secondary analysis at the later time points, adjusting for breastfeeding duration. We explored when the main group differences in growth emerged in order to estimate the largest ‘effect periods’. Results After adjusting for socioeconomic status and maternal education, HEU children had lower weight-for-age, length-for-age and BMI-for-age Z-scores during early growth and these differences still existed when children were school-aged. Exposure group differences changed most between 1 and 6 weeks and between 18 months and ~7.5 years. Conclusions HEU children have poorer early growth than HUU children which persists into later growth. Interventions to improve growth of HEU children need to target pregnant women and infants.
机译：背景暴露于艾滋病毒的未感染儿童的早期生长情况比未暴露于艾滋病毒的未感染儿童的早期生长情况要差，但是关于早期暴露于艾滋病毒的生长影响的纵向或长期信息很少。方法我们使用来自赞比亚卢萨卡的两项队列研究的数据进行了纵向分析，以比较HEU和HUU婴儿和儿童的生长情况。最初，来自母乳喂养和产后健康（BFPH）研究的207 HUU和200 HEU婴儿，以及来自Chilenjeje婴儿生长，营养和感染研究（CIGNIS）的580 HUU和165 HEU在婴儿期以及学龄时再次进行了人体测量。那时有66名BFPH儿童和326名CIGNIS儿童可供使用。我们使用线性混合模型分别分析了两个队列的数据。在以后的时间点，将线性回归模型用作辅助分析，以调整母乳喂养时间。我们研究了主要人群的增长差异何时出现，以便估算最大的“影响期”。结果经过调整社会经济地位和孕产妇教育后，HEU儿童在早期生长期间的年龄体重，年龄长度和BMI年龄Z得分较低，这些差异在学龄儿童中仍然存在。暴露组差异在1至6周之间以及18个月至〜7.5年之间变化最大。结论HEU儿童的早期生长较HUU儿童低，后者一直持续到后期生长。改善HEU儿童生长的干预措施需要针对孕妇和婴儿。

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