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首页> 外文期刊>BMC Neuroscience >Modulatory effect of adenosine receptors on the ascending and descending neural reflex responses of rat ileum
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Modulatory effect of adenosine receptors on the ascending and descending neural reflex responses of rat ileum

机译：腺苷受体对大鼠回肠上升和下降神经反射反应的调节作用

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Background Adenosine is known to act as a neuromodulator by suppressing synaptic transmission in the central and peripheral nervous system. Both the release of adenosine within the small intestine and the presence of adenosine receptors on enteric neurons have been demonstrated. The aim of the present study was to characterize a possible involvement of adenosine receptors in the modulation of the myenteric reflex. The experiments were carried out on ileum segments 10 cm in length incubated in an single chambered organ bath, and the reflex response was initiated by electrical stimulation (ES). Results ES caused an ascending contraction and a descending relaxation followed by a contraction. All motility responses to ES were completely blocked by tetrodotoxin, indicating that they are mediated by neural mechanisms. Atropine blocked the contractile effects, whereas the descending relaxation was significantly increased. The A1 receptor agonist N6-cyclopentyladenosine increased the ascending contraction, whereas the ascending contraction was reduced by the A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine. Activation of the A1 receptor further reduced the descending relaxation and the latency of the peristaltic reflex. The A2B receptor antagonist alloxazine increased ascending contraction, whereas descending relaxation remained unchanged. For A2A and A3 receptors, we found contradictory effects of the agonists and antagonists, thus there is no clear physiological role for these receptors at this time. Conclusions This study suggests that the myenteric ascending and descending reflex response of the rat small intestine is modulated by release of endogenous adenosine via A1 receptors.
机译：背景技术已知腺苷通过抑制中枢和周围神经系统中的突触传递而充当神经调节剂。小肠内腺苷的释放和肠神经元上腺苷受体的存在均已得到证实。本研究的目的是表征腺苷受体可能参与肌层反射的调节。在单个腔室器官浴中温育的回肠段长度为10 cm上进行实验，并通过电刺激（ES）启动反射反应。结果ES引起收缩上升和收缩下降。河豚毒素完全阻断了对ES的所有运动反应，表明它们是由神经机制介导的。阿托品阻断了收缩作用，而下降的松弛作用显着增加。 A 1 受体激动剂N6-环戊基腺苷增加了收缩，而A 1 受体拮抗剂8-环戊基-1,3-二丙基黄嘌呤减少了收缩。 A 1 受体的激活进一步降低了蠕动反射的下降松弛和潜伏期。 A 2B 受体拮抗剂阿洛嗪增加了上升收缩，而下降松弛保持不变。对于A 2A 和A 3 受体，我们发现激动剂和拮抗剂的作用相反，因此目前这些受体尚无明确的生理作用。结论这项研究表明，大鼠小肠的肌间升反射反应是通过A 1 受体释放内源性腺苷来调节的。

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