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首页> 外文期刊>BMC Neuroscience >LOC689986 , a unique gene showing specific expression in restricted areas of the rodent neocortex
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LOC689986 , a unique gene showing specific expression in restricted areas of the rodent neocortex

机译：LOC689986，一个独特的基因，在啮齿动物新皮质的限制区域显示特异性表达

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Background The neocortex is a highly specialised and complex brain structure, involved in numerous tasks, ranging from processing and interpretation of somatosensory information, to control of motor functions. The normal function linked to distinct neocortical areas might involve control of highly specific gene expression, and in order to identify such regionally enriched genes, we previously analysed the global gene expression in three different cortical regions (frontomedial, temporal and occipital cortex) from the adult rat brain. We identified distinct sets of differentially expressed genes. One of these genes, namely the hypothetical protein LOC689986 ( LOC689986 ), was of particular interest, due to an almost exclusive expression in the temporal cortex. Results Detailed analysis of LOC689986 in the adult rat brain confirmed the expression in confined areas of parieto-temporal cortex, and revealed highly specific expression in layer 4 of the somatosensory cortex, with sharp borders towards the neighbouring motor cortex. In addition, LOC689986 was found to be translated in vivo , and was detected in the somatosensory cortex and in the Purkinje cells of the cerebellar cortex. The protein was present in neuronal dendrites and also in astrocyte cells. Finally, this unique gene is apparently specific for, and highly conserved in, the vertebrate lineage. Conclusions In this study, we have partially characterised the highly conserved LOC689986 gene, which is specific to the vertebrate linage. The gene displays a distinct pattern of expression in layer 4 of the somatosensory cortex, and areas of the parieto-temporal cortex in rodents.
机译：背景技术新皮层是高度专业化的复杂大脑结构，涉及许多任务，从处理和解释体感信息到控制运动功能。与不同的新皮层区域相关的正常功能可能涉及控制高度特异性的基因表达，为了鉴定这种区域丰富的基因，我们之前分析了成年成年人在三个不同皮层区域（额叶，颞叶和枕叶皮层）的整体基因表达老鼠的大脑。我们确定了差异表达基因的不同集合。这些基因之一，即假设的蛋白质LOC689986（LOC689986），由于在颞皮质中几乎是排他性表达而特别受关注。结果对成年大鼠大脑中LOC689986的详细分析证实了该蛋白在顶颞叶皮质的狭窄区域中的表达，并揭示了在体感皮质的第4层中具有高度特异性的表达，并与相邻的运动皮质有明显的边界。此外，发现LOC689986可在体内翻译，并在体感皮层和小脑皮层的Purkinje细胞中检测到。该蛋白质存在于神经元树突和星形胶质细胞中。最后，这个独特的基因显然对脊椎动物谱系具有特异性，并且在脊椎动物谱系中高度保守。结论在这项研究中，我们已部分表征了高度保守的LOC689986基因，该基因特异于脊椎动物linage。该基因在啮齿动物的体感皮层的第4层和顶颞皮层的区域中表现出不同的表达模式。

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